Advertisement

Species differences in changes of heart monoamine oxidase activities with age

  • M. Strolin Benedetti
  • J. Thomassin
  • P. Tocchetti
  • P. Dostert
  • R. Kettler
  • M. Da Prada
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 41)

Summary

It has previously been established that MAO-A activity markedly increases (about 600%) with age in the rat heart. The aim of the present study was to examine the effect of age on the activity of MAO-A and -B in the mouse heart.

In contrast to the rat heart, β-phenylethylamine is deaminated by MAO-B in the mouse heart. Heart MAO-B activity was found to significantly increase (about 70%) with age in both male and female mice, whereas MAO-A activity remained unchanged. Compared to age-matched rats, serotonin-deaminating activity was about 35 times and 204 times lower in young and old mice, respectively.

Keywords

Monoamine Oxidase Young Mouse Mouse Heart Oxidative Deamination Whole Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248–254.PubMedCrossRefGoogle Scholar
  2. Cao Danh H, Strolin Benedetti M, Dostert P (1984) Differential changes in monoamine oxidase A and B activity in aging rat tissues. In: Tipton KF, Dostert P, Strolin Benedetti M (eds) Monoamine oxidase and disease. Prospects for therapy with reversible inhibitors. Academic Press, London, pp 301–317.Google Scholar
  3. Fuentes JA, Trepel JB, Neff NH (1977) Monoamine oxidase activity in the cardiovascular system of young and aged rats. Exp Gerontol 12: 113–115.PubMedCrossRefGoogle Scholar
  4. Horita A, Lowe MC (1972) On the extraneuronal nature of cardiac monoamine oxidase in the rat. Adv Biochem Psychopharmacol 5: 227–242.PubMedGoogle Scholar
  5. Novick WJ (1961) The effect of age and thyroid hormones on the monoamine oxidase of rat heart. Endocrinology 69: 55–59.PubMedCrossRefGoogle Scholar
  6. Parkinson D, Callingham BA (1979) Substrate and inhibitor selectivity of human heart monoamine oxidase. Biochem Pharmacol 28: 1639–1643.PubMedCrossRefGoogle Scholar
  7. Strolin Benedetti M, Dostert P, Guffroy C, Tipton KF (1983) Partial or total protection from long-lasting monoamine oxidase inhibitors (MAOIs) by new short-acting MAOIs of type A MD 780515 and type B MD 780236. Mod Probi Pharmaco-psychiatry 19: 82–104.Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • M. Strolin Benedetti
    • 1
  • J. Thomassin
    • 1
  • P. Tocchetti
    • 1
  • P. Dostert
    • 1
  • R. Kettler
    • 2
  • M. Da Prada
    • 2
  1. 1.Farmitalia Carlo Erba, Research and Development — Erbamont GroupMilanItaly
  2. 2.Pharmaceutical Research DepartmentF. Hoffmann-La Roche Ltd.BaselSwitzerland

Personalised recommendations