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Dopaminergic cell death in Parkinson’s disease: a role of iron?

  • F. Javoy-Agid
  • B. Faucheux
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Loss of midbrain dopaminergic neurons in Parkinson’s disease is associated to hyperoxidation phenomena. In the human substantia nigra, free radicals may be produced in large quantities i.e, during degradation of dopamine, synthesis and accumulation of neuromelanin, through iron, present in high concentrations. Under normal conditions, production of free radicals is compensated by powerful protective enzymes: superoxide dismutase is detected in neurons, and expressed at high levels in those of the substantia nigra; gluthatione peroxidase is exclusively detected in glial cells. A low density of glial cells surround the substantia nigra neurons relatively to other midbrain areas. Thus nigral dopaminergic neurons may be less protected against deleterious action of free radicals. This may explain their preferential susceptibility to oxidative stress. In Parkinson’s disease, an overproduction of free radicals, suggested by the increased level of lipid peroxidation in the substantia nigra, might accelerate the rate of dopaminergic cells death. Impairment of the oxygen toxicity protective mechanisms may be responsible. Besides, the above normal levels of iron in the substantia nigra may contribute to free radical production and have a role in the toxic process, though one cannot exclude the increased iron content may be a non-specific product of cellular degeneration, a consequence of the gliosis.

Keywords

Substantia Nigra Dopaminergic Neuron Ventral Tegmental Area Progressive Supranuclear Palsy Midbrain Dopaminergic Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • F. Javoy-Agid
    • 1
  • B. Faucheux
    • 1
  1. 1.Hôpital de la SalpêtrièreINSERM U 289ParisFrance

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