Some reflections on iron dependent free radical damage in the central nervous system

  • M. E. Götz
  • A. Dirr
  • W. Gsell
  • R. Burger
  • A. Freyberger
  • P. Riederer
Part of the Key Topics in Brain Research book series (KEYTOPICS)


We give a brief introduction into the chemical relationship between iron and oxidative stress serving two purposes:

Firstly we will mention possible deleterious consequences of iron accumulation in central nervous system (CNS) to biomolecules essential for cell viability. Secondly, we try to discuss some difficulties scientists have to face when interpreting experimental data by which they want to prove or to rule out a role of reactive oxygen species (ROS) in the pathogenesis or progression of human diseases.


Nervous System Disorder Lipid Soluble Antioxidant Water Soluble Antioxidant Parkinson Study Group Pink Pigment 


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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • M. E. Götz
    • 1
  • A. Dirr
    • 1
  • W. Gsell
    • 1
  • R. Burger
    • 1
  • A. Freyberger
    • 2
  • P. Riederer
    • 1
  1. 1.Division of Clinical Neurochemistry, Department of PsychiatryUniversity of WürzburgWuppertalFederal Republic of Germany
  2. 2.Institute of ToxicologyBayer AG Pharma ForschungszentrumWuppertalFederal Republic of Germany

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