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Consequences of intrastriatally administrated FeCl3 and 6-OHDA without and after transient cerebral oligemia on behaviour and navigation

A free radical related tissue damage?

  • Conference paper
Iron in Central Nervous System Disorders

Part of the book series: Key Topics in Brain Research ((KEYTOPICS))

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Summary

6-OHDA (6 or 8 µg) unilaterally applied into the ventrolateral striatum induces neurotoxic effects which lead to unilateral hyperactivity triggering contralateral turning and rotations after apomorphine administration. Treatment with alpha-tocopherol prevents the hypersensitive reaction. The sensitivity of the cerebral tissue to apomorphine following 6-OHDA treatment is enhanced when 7.5 µg FeCl3 is coadministered with 6-OHDA. Only when the combination of 6-OHDA and FeCl3 is administered the escape latency to find a hidden platform in a water maze-test increased as measured 12 weeks later. The night activity of such treated animals was markedly reduced. Remarkable effects of unilaterally applied FeCl3 (0.06–1.5 ug) were observed in old rats, and in rats after transient cerebral oligemia. Apomorphine treatment to such animals induced rotations. It is possible, therefore, that mild to moderate transient or permanent local oxygen deficits together with iron cause progressive damage to vulnerable cerebral tissue. Such an effect would be comparable to the neurotoxicity of 6-OHDA possibly involve free radicals and lipid peroxidation.

On leave: Institute of Pharmacology, Polish Academy of Science, Krakow, Poland

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Authors and Affiliations

  1. Department of Pharmacology, Max-Planck-Institute for Experimental Medicine, Göttingen, Federal Republic of Germany

    W. Kolasiewicz, T. Jaros & K.-H. Sontag

  2. Department of Psychiatry, University of Göttingen, Göttingen, Federal Republic of Germany

    Dr. C. Heim

  3. Veterinär-biologisches Labor, Northeim, Federal Republic of Germany

    W. Kolasiewicz, T. Jaros & K.-H. Sontag

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  1. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    Peter Riederer

  2. Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel

    M. B. H. Youdim

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Heim, C., Kolasiewicz, W., Jaros, T., Sontag, KH. (1993). Consequences of intrastriatally administrated FeCl3 and 6-OHDA without and after transient cerebral oligemia on behaviour and navigation. In: Riederer, P., Youdim, M.B.H. (eds) Iron in Central Nervous System Disorders. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9322-8_11

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  • DOI: https://doi.org/10.1007/978-3-7091-9322-8_11

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