Pathogenesis of Parkinson’s disease: iron and mitochondrial DNA deletion

  • Y. Mizuno
  • H. Mochizuki
  • K. Nishi
  • S.-i. Ikebe
  • N. Hattori
  • Y. Hattori-Nakagawa
Part of the Key Topics in Brain Research book series (KEYTOPICS)


Numbers of biochemical abnormalities which may be relevant to the degenerative process of nigral dopaminergic neurons have been described. These include accumulation of iron in substantia nigra, decrease in the enzymatic activity and the amount of subunits of mitochondrial complex I, increase in the amount of deleted mitochondrial DNA, and possible increase in oxygen derived free radicals. Recent progress in this field is reviewed in this communication. Although the primary cause of Parkinson’s disease is still unknown, these abnormalities listed above will contribute to the progression of the degenerative process. In addition, we report our recent data on the toxic effects of iron and synthetic dopamine melanin on cultured dopaminergic neurons, and discuss possible interaction of iron and mitochondrial DNA.


Substantia Nigra Ubiquinone Oxidoreductase Nigral Neuron Parkinsonian Brain Electron Transfer Complex 


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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • Y. Mizuno
    • 2
  • H. Mochizuki
    • 1
  • K. Nishi
    • 1
  • S.-i. Ikebe
    • 1
  • N. Hattori
    • 1
  • Y. Hattori-Nakagawa
    • 1
  1. 1.Department of NeurologyJuntendo University School of MedicineJapan
  2. 2.Department of NeurologyJuntendo University School of MedicineBunkyo, Tokyo 113Japan

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