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Iron in Central Nervous System Disorders pp 117–135Cite as

Pathogenesis of Parkinson’s disease: iron and mitochondrial DNA deletion

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Part of the book series: Key Topics in Brain Research ((KEYTOPICS))

Summary

Numbers of biochemical abnormalities which may be relevant to the degenerative process of nigral dopaminergic neurons have been described. These include accumulation of iron in substantia nigra, decrease in the enzymatic activity and the amount of subunits of mitochondrial complex I, increase in the amount of deleted mitochondrial DNA, and possible increase in oxygen derived free radicals. Recent progress in this field is reviewed in this communication. Although the primary cause of Parkinson’s disease is still unknown, these abnormalities listed above will contribute to the progression of the degenerative process. In addition, we report our recent data on the toxic effects of iron and synthetic dopamine melanin on cultured dopaminergic neurons, and discuss possible interaction of iron and mitochondrial DNA.

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Authors and Affiliations

  1. Department of Neurology, Juntendo University School of Medicine, Japan

    H. Mochizuki, K. Nishi, S.-i. Ikebe, N. Hattori & Y. Hattori-Nakagawa

  2. Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo 113, Japan

    Dr. Y. Mizuno

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  1. Dr. Y. Mizuno
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  2. H. Mochizuki
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  3. K. Nishi
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  4. S.-i. Ikebe
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  5. N. Hattori
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  6. Y. Hattori-Nakagawa
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  1. Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    Peter Riederer

  2. Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel

    M. B. H. Youdim

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Mizuno, Y., Mochizuki, H., Nishi, K., Ikebe, Si., Hattori, N., Hattori-Nakagawa, Y. (1993). Pathogenesis of Parkinson’s disease: iron and mitochondrial DNA deletion. In: Riederer, P., Youdim, M.B.H. (eds) Iron in Central Nervous System Disorders. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9322-8_10

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  • DOI: https://doi.org/10.1007/978-3-7091-9322-8_10

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