Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in ducks

  • Lucyna Cova
  • Agnes Duflot
  • M. Prave
  • C. Trepo
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 8)


The association between chronic infection by hepadnaviruses isolated from human (HBV), woodchuck (WHV), ground squirrel (GSHV) and development of hepatocellular carcinoma (HCC) in their respective hosts is well established (reviewed in [11, 15, 17]). By contrast, the association of duck hepatitis B virus (DHBV) infection with HCC is less documented. Pekin ducks congenitally infected with DHBV and followed for several years throughout the world do not develop liver tumors: HCC has been found only in domestic ducks from a single area of China, Qidong. Several factors such as DHBV carrier rate, breed and age of ducks, subtype of DHBV and environmental carcinogens are suspected to contribute to this striking difference between the geographical repartition of liver cancer in DHBV-carrier ducks. In this brief review we will consider successively the role of these different factors in duck liver oncogenesis.


Ground Squirrel Domestic Duck Pekin Duck Duck Hepatitis Commercial Flock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Lucyna Cova
    • 1
  • Agnes Duflot
    • 1
  • M. Prave
    • 2
  • C. Trepo
    • 1
  1. 1.INSERM U271LyonFrance
  2. 2.Ecole Nationale Veterinaire de LyonLyonFrance

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