Advertisement

Hepatitis C virus infection in liver allograft recipients

  • L. Caccamo
  • M. Colledan
  • B. Gridelli
  • G. Rossi
  • M. Doglia
  • S. Gatti
  • P. Ghidoni
  • A. Lucianetti
  • G. Lunghi
  • U. Maggi
  • G. Paone
  • P. Reggiani
  • D. Galmarini
  • L. R. Fassati
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 8)

Summary

The impact of HCV infection after liver transplantation remains a topic of discussion. The aims of this study were to define the prevalence of anti-HCV antibodies in liver donors; the risk of acquired HCV infection and HCV re-infection according to the pre-transplant anti-HCV status; the prevalence of HCV infection in post-transplant chronic hepatitis. Sera from 42 recipients with follow up longer than 6 months and their donors were tested for anti-HCV. By results at pre-transplant time patients were classified as follows: donor (D) negative and recipient (R) negative (D−/R−) 31; D−/R+ 9; D+ /R− 1; D+ /R+ 1. Twenty-one patients with sustained hepatic dysfunction underwent liver biopsy. In group D−/R−, 5 patients showed anti-HCV positivity and 3 (9.7%) of them had acquired HCV hepatitis. In group D−/R+, 6 patients showed persistent anti-HCV positivity and 4 (44.4%) of them had recurrent HCV hepatitis; of these 2 died due to liver failure. The 2 patients of groups D+/R- and D+/R+ had normal liver function. Anti-HCV negative hepatitis was found in 2 patients. The prevalence of anti-HCV positivity in liver donors appeared low (3.2%). Acquired HCV infection rate was 9.7%. Pre-transplant HCV infection led to a high incidence of recurrence (44.4%). HCV was the major etiological agent in post-transplant chronic hepatitis (77.8%).

Keywords

Liver Donor Liver Transplant Recipient Hepatitis Delta Virus Biliary Anastomotic Stenosis Liver Allograft Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Alberti A, Morsica G, Chemello L, Cavalletto D, Noventa F, Pontisso P, Ruol A (1992) Hepatitis C viraemia and liver disease in sympton-free individuals with anti- HCV. Lancet 340: 697–698PubMedCrossRefGoogle Scholar
  2. 2.
    Alter HJ (1992) New kit on the block: evaluation of second-generation assays for detection of antibody to the hepatitis C virus. Hepatology 15: 350–353PubMedCrossRefGoogle Scholar
  3. 3.
    Colledan M, Grendele M, Gridelli B, Rossi G, Fassati LR, Ferla G, Doglia M, Gislon M, Galmarini D (1989) Long-term results after liver transplantation in B and Delta hepatitis. Transplant Proc 21: 2421–2423PubMedGoogle Scholar
  4. 4.
    Colina F, Mollejo M, Moreno E, Alberti N, Garcia I, Gomez-Sanz R, Castellano G (1991) Effectiveness of histopathological diagnoses in dysfunction of hepatic transplantation. Review of 146 histopathological studies from 53 transplants. Arch Pathol Lab Med 115: 998–1005PubMedGoogle Scholar
  5. 5.
    Crippin JS, Carlen SL, Borcich A, Bodenheimer HC Jr (1992) Retransplantation in hepatitis B: a multicenter experience. Hepatology 16: 277AGoogle Scholar
  6. 6.
    Donegan E, Wright TL, Kim M, Roberts J, Ascher N, Wiber J, Chan S, Qaun S, Detmer J, Polito A, Urdea M (1992) Diagnosis of hepatitis C viral (HCV) infection in liver transplant recipients. Hepatology 16: 70AGoogle Scholar
  7. 7.
    Feray C, Gigou M, Samuel D, Thiers V, Paradis V, David MF, Reynes M, Brechot C, Bismuth H (1992) Natural history of hepatitis C virus (HCV) infection after liver transplantation (LT). Hepatology 16: 47AGoogle Scholar
  8. 8.
    Ferrell LD, Wright TL, Roberts J, Ascher N, Lake J (1992) Hepatitis C viral infection in liver transplant recipients. Hepatology 16: 865 - 876PubMedCrossRefGoogle Scholar
  9. 9.
    Freese D, Ho S, Snover D, Bloomer J, Rank J, Sharp H, Knaak M, Allen J, Hamman K, Payne W (1992) Chronic hepatitis after liver transplantation: etiology and outcome. Hepatology 16: 48ACrossRefGoogle Scholar
  10. 10.
    Gimeno C, Lumbreras C, Colina F, Fuertes A, Lizasoanin M, Aguado JM, Loinaz C, Iglesias J, Moreno E, Noriega AR (1992) Value of a new four-antigen recombinant immunoblott assay (4-RIBA) in predicting recurrence of hepatitis C virus infection following liver transplantation (LT). The Jean Hamburger memorial congress, XIVth international congress of the Transplantation Society. Symposium and poster abstracts, Paris, August 16–21 1992, p 613Google Scholar
  11. 11.
    Gretch DR, Dela Rosa C, Perkins J, Carithers RL Jr (1992) HCV infection in liver transplantation recipients: chronic reinfection universal, de novo acquisition rare. Gastroenterology 16: 45AGoogle Scholar
  12. 12.
    Houghton M, Weiner A, Han J, Kuo G, Choo Q-L (1992) Molecular biology of the hepatitis C virus: implications for diagnosis, development and control of viral disease. Hepatology 14: 381–388CrossRefGoogle Scholar
  13. 13.
    Kuo G, Choo QL, Alter JH, Gitnik GL, Redeker AG, Purcell RH, Miyamura T, Dienstag JL, Alter MJ, Stevens CE, Tegtmeier GE, Bonino F, Colombo M, Lee WS, Kuo D, Berger K, Shuster JR, Overby LR, Bradley DW, Oughton M (1989) An assay for circulating antibodies to a major etiologic virus of human non-A, non- B hepatitis. Science 244: 362–364PubMedCrossRefGoogle Scholar
  14. 14.
    Jeffers LJ, Hasan F, De Medina M, Reddy R, Parker T, Silva M, Mendez L, Schiff ER, Manns M, Houghton M, Choo Q-L, Kou G (1992) Prevalence of antibodies to hepatitis C virus among patients with cryptogenetic chronic hepatitis and cirrhosis. Hepatology 15: 187–190PubMedCrossRefGoogle Scholar
  15. 15.
    Li X, Jeffers L, Reddy R, De Medina M, Parker T, Schiff ER (1992) Detection of HCV-RNA by RT-PCR in lymphocyte subsets. Gastroenterology 102: A842Google Scholar
  16. 16.
    Marcellin P, Samuel D, Loriot MA, Gigou M, Benhamou JP, Bismuth H (1991) Use of AR A-AMP in liver transplant patients with HBV graft infection. 5 th Congress of European Society for Organ Transplantation, book of abstracts, Maastricht, October 7–10 1991, p 273Google Scholar
  17. 17.
    Martin P, Munoz SJ, Di Bisceglie AM, Rubin R, Waggoner JG, Armenti VT, Moritz MJ, Jarrell BE, Maddrey WC (1991) Recurrence of hepatitic C virus infection after orthotopic liver transplantation. Hepatology 13: 719–721PubMedCrossRefGoogle Scholar
  18. 18.
    Martin P, Munoz SJ, Friedman LS (1992) Liver transplantation for viral hepatitis: current status. Am J Gastroenterol 87: 409–418PubMedGoogle Scholar
  19. 19.
    McHutchinson JG, Person JL, Govindarajan, Valinluck B, Gore T, Lee SR, Nelles M, Polito A, Chien D, DiNello R, Quan S, Kuo G, Redeker AG (1992) Improved detection of hepatitis C virus antibodies in high-risk populations. Hepatology 15: 19–25CrossRefGoogle Scholar
  20. 20.
    Müller H, Otto G, Goeser T, Arnold J, Pfaff J, Thielmann L (1992) Recurrence of hepatitis C virus infection after orthotopic liver transplantation. Transplantation 54: 743–745PubMedCrossRefGoogle Scholar
  21. 21.
    Nakatsuji Y, Matsumoto A, Tanaka E, Ogata H, Kiyosawa K (1992) Detection of chronic hepatitis C virus by four diagnostic systems: first-generation and second- generation enzyme-linked immunosorbent assay, second-generation recombinant immunoblot assay and polimerase chain reaction analysis. Hepatology 16: 300–305PubMedCrossRefGoogle Scholar
  22. 22.
    Nakhleh RE, Schwarzenberg SJ, Bloomer J, Payne W, Snover DC (1990) The pathology of liver allografts surviving longer than one year. Hepatology 11: 465–470PubMedCrossRefGoogle Scholar
  23. 23.
    New L, Korb S, Brown M, Light JA, Alarif L (1992) The clinical implications of transplanting hepatitis C positive donor organ. The Jean Hamburger memorial congress, XIVth international congress of the Transplantation Society. Symposium and poster abstracts, Paris, August 16–21 1992, p 805Google Scholar
  24. 24.
    Pereira BJG, Milford EL, Kirkman RL, Levey AS (1991) Transmission of hepatitis C virus by organ transplantation. N Engl J Med 325: 454–460PubMedCrossRefGoogle Scholar
  25. 25.
    Pereira BJG, Milford EL, Kirkman RL, Quan S, Sayre KR, Johnson PJ, Wilber JC, Levey AS (1992) Prevalence of hepatitis C virus in organ donors positive for hepatitis C antibody and in the recipients of their organs. N Engl J Med 327: 910–915PubMedCrossRefGoogle Scholar
  26. 26.
    Pirsch JD, Beizer FO (1992) Transmission of HCV by organ transplantation. N Engl J Med 326: 412PubMedGoogle Scholar
  27. 27.
    Poterucha JJ, Rakela J, Ludwig J, Taswell HF, Wiesner RH (1991) Hepatitis C antibodies in patients with chronic hepatitis of unknown etiology after orthotopic liver transplantation. Transplant Proc 23: 1495–1497PubMedGoogle Scholar
  28. 28.
    Pouterucha JJ, Rakela J, Lumeng L, Lee C-H, Taswell HF, Wiesner RH (1992) Diagnosis of chronic hepatitis C after liver transplantation by detection of viral sequences by polymerase chain reaction. Hepatology 15: 42–45CrossRefGoogle Scholar
  29. 29.
    Quiroga J, Colina I, Demetris JA, Starzl TE, Van Thiel D (1991) Cause and timing of first allograft failure in orthotopic liver transplantation: a study of 177 consecutive patients. Hepatology 14: 1054–1062PubMedCrossRefGoogle Scholar
  30. 30.
    Rizzetto M, Macagno S, Chiaberge E, Verme G, Negro F, Marinucci G, Di Giacomo C, Alfani D, Cortesini R, Milazzo F, Doglia M, Fassati LR, Galmarini D (1987) Liver transplantation in hepatitis delta virus disease. Lancet ii: 469–471Google Scholar
  31. 31.
    Rossi G, Grendele M, Colledan M, Gridelli B, Fassati LR, Maggi U, Reggiani P, Gatti S, Piazzini A, Lunghi G, Cardone R, Galmarini D (1989) Prevention of hepatitis B virus reinfection after liver transplantation. Transplant Proc 23: 1969Google Scholar
  32. 32.
    Sallie R, Cohen A, Rayner A, O’Grady J, Tan KC, Portman B, Williams R (1992) Hepatitis ”C“ recurrence following orthotopic liver transplantation: a PCR and histological study. Hepatology 16: 48ACrossRefGoogle Scholar
  33. 33.
    Samuel D, Bismuth A, Matheiu D, Arulnaden J-L, Reynes M, Benhamou J-P, Brechot C, Bismuth H (1991) Passive immunoprophylaxis after liver transplantation in HBsAg-positive patients. Lancet 337: 813–815PubMedCrossRefGoogle Scholar
  34. 34.
    Samuel D, Gigou M, Feray C, David MF, Reynes M, Brechot C, Bismuth H (1992) Recombinant alpha interferon for hepatitis C on the graft in liver transplant patients. Hepatology 16: 48ACrossRefGoogle Scholar
  35. 35.
    Shah G, Demetris AJ, Gavaler JS, Lewis JH, Todo S, Starzl TE, Van Thiel DH (1992) Incidence, prevalence and clinical course of hepatitis C in liver transplantation. Gastroenterology 103: 323–329PubMedGoogle Scholar
  36. 36.
    Todo S, Demetris AJ, Van Thiel D, Teperman L, Fung JJ, Starzl TE (1991) Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease. Hepatology 13: 619–626PubMedGoogle Scholar
  37. 37.
    Trainor T, Farr G, Cooper S, Hayes D, Regenstein F, Balart L (1990) Anti-body to hepatitis C (anti-HCV) in orthotopic liver transplant (OLTx) recipients. Hepatology 12: 866Google Scholar
  38. 38.
    Villamil F, Yu C-H, Hu K-Q, Makowka L, Podesta L, Sher L, Howard T, Memsic L, Hoffman A, Petrovic L, Aziz H, Vierling J (1992) Alfa 2b-interferon (alfa2b- IFN) therapy of hepatitis C following liver transplantation (LT). Hepatology 16: 48ACrossRefGoogle Scholar
  39. 39.
    Wang JT, Wang T-H, Sheu J-C, Lin J-T, Wang C-Y, Chen D-S (1992) Posttransfusion hepatitis revisited by hepatitis C antibody assays and polymerase chain reaction. Gastroenterology 103: 609–616PubMedGoogle Scholar
  40. 40.
    Wreighitt TG, Gray JJ, Allain JP, Porlain J, Garson R, Calne RY, Large S, Wallwork J, Alexander DJ (1992) Frequent transmission of hepatitis C virus by organ donation. Hepatology 16: 47AGoogle Scholar
  41. 41.
    Wright HI, Gavaler JS, Van Thiel DH (1992) Preliminary experience with alpha- 2b-interferon therapy of viral hepatitis in liver allograft recipients. Transplantation 53: 121–124PubMedCrossRefGoogle Scholar
  42. 42.
    Wright TL, Donegan E, Hsu HH, Ferrel L, Lake JR, Kim M, Combs C, Fennessy S, Roberts JP, Ascher NL, Greenberg HB (1992) Recurrent and acquired hepatitic C viral infection in liver transplant recipients. Gastroenterology 103: 317–322PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • L. Caccamo
    • 1
  • M. Colledan
    • 1
  • B. Gridelli
    • 1
  • G. Rossi
    • 1
  • M. Doglia
    • 1
  • S. Gatti
    • 1
  • P. Ghidoni
    • 2
  • A. Lucianetti
    • 1
  • G. Lunghi
    • 3
  • U. Maggi
    • 1
  • G. Paone
    • 1
  • P. Reggiani
    • 1
  • D. Galmarini
    • 1
  • L. R. Fassati
    • 1
  1. 1.Istituto di Chirurgia Sperimentale e dei Trapianti Centro Trapianto FegatoUniversità di Milano, Ospedale Maggiore I.R.C.C.S.MilanoItaly
  2. 2.Istituto di Anatomia e Istologia PatologicaUniversità di Milano, Ospedale Maggiore I.R.C.C.S.MilanItaly
  3. 3.Istituto di IgieneUniversità di Milano, Ospedale Maggiore I.R.C.C.S.MilanItaly

Personalised recommendations