Hepatitis C virus infection in liver allograft recipients

  • L. Caccamo
  • M. Colledan
  • B. Gridelli
  • G. Rossi
  • M. Doglia
  • S. Gatti
  • P. Ghidoni
  • A. Lucianetti
  • G. Lunghi
  • U. Maggi
  • G. Paone
  • P. Reggiani
  • D. Galmarini
  • L. R. Fassati
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 8)


The impact of HCV infection after liver transplantation remains a topic of discussion. The aims of this study were to define the prevalence of anti-HCV antibodies in liver donors; the risk of acquired HCV infection and HCV re-infection according to the pre-transplant anti-HCV status; the prevalence of HCV infection in post-transplant chronic hepatitis. Sera from 42 recipients with follow up longer than 6 months and their donors were tested for anti-HCV. By results at pre-transplant time patients were classified as follows: donor (D) negative and recipient (R) negative (D−/R−) 31; D−/R+ 9; D+ /R− 1; D+ /R+ 1. Twenty-one patients with sustained hepatic dysfunction underwent liver biopsy. In group D−/R−, 5 patients showed anti-HCV positivity and 3 (9.7%) of them had acquired HCV hepatitis. In group D−/R+, 6 patients showed persistent anti-HCV positivity and 4 (44.4%) of them had recurrent HCV hepatitis; of these 2 died due to liver failure. The 2 patients of groups D+/R- and D+/R+ had normal liver function. Anti-HCV negative hepatitis was found in 2 patients. The prevalence of anti-HCV positivity in liver donors appeared low (3.2%). Acquired HCV infection rate was 9.7%. Pre-transplant HCV infection led to a high incidence of recurrence (44.4%). HCV was the major etiological agent in post-transplant chronic hepatitis (77.8%).


Liver Donor Liver Transplant Recipient Hepatitis Delta Virus Biliary Anastomotic Stenosis Liver Allograft Recipient 
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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • L. Caccamo
    • 1
  • M. Colledan
    • 1
  • B. Gridelli
    • 1
  • G. Rossi
    • 1
  • M. Doglia
    • 1
  • S. Gatti
    • 1
  • P. Ghidoni
    • 2
  • A. Lucianetti
    • 1
  • G. Lunghi
    • 3
  • U. Maggi
    • 1
  • G. Paone
    • 1
  • P. Reggiani
    • 1
  • D. Galmarini
    • 1
  • L. R. Fassati
    • 1
  1. 1.Istituto di Chirurgia Sperimentale e dei Trapianti Centro Trapianto FegatoUniversità di Milano, Ospedale Maggiore I.R.C.C.S.MilanoItaly
  2. 2.Istituto di Anatomia e Istologia PatologicaUniversità di Milano, Ospedale Maggiore I.R.C.C.S.MilanItaly
  3. 3.Istituto di IgieneUniversità di Milano, Ospedale Maggiore I.R.C.C.S.MilanItaly

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