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The relationship between LeY antigen and the therapeutic efficacy of interferon in chronic hepatitis C

  • M. Sata
  • H. Nakano
  • T. Hino
  • T. Kosedo
  • M. Adachi
  • K. Tanikawa
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 8)

Summary

The expression of LeY antigen (Fuc α 1 → 2Gal β 1 → 4 [Fuc α → 3] GlcNAc β 1 → R), recognized by the monoclonal antibody BM-1, was studied in peripheral blood T-lymphocyte subpopulations in patients with viral hepatitis, and in liver tissue of patients with acute viral hepatitis. The relationship between the expression of LeY antigen on peripheral blood T-lymphocytes and the effects of interferon (IFN) therapy for chronic hepatitis type C were also evaluated. LeY antigen is not markedly expressed in B or T-lymphocytes of healthy individuals. However, it was strongly expressed in CD8 and CD4 T-lymphocytes in patients with viral hepatitis. In the acute phase of acute viral hepatitis, the expression of LeY antigen was more markedly expressed on peripheral CD8 T-lymphocytes than on CD4 T-lymphocytes. In chronic hepatitis type B and type C, it was significantly expressed more often on CD4 T-lymphocytes. In the liver tissues of patients with acute viral hepatitis, LeY antigen was expressed on hepatocytes and infiltrating lymphocytes. IFN therapy for chronic active hepatitis type C proved most effective when LeY antigen was more markedly expressed on the patient’s CD4 and CD8 peripheral blood T-lymphocytes before treatment. Further studies are needed to clarify the relationship between the mechanisms of hepatic cell injury and LeY antigen.

Keywords

Chronic Hepatitis Acute Hepatitis Acquire Immune Deficiency Syndrome Carbohydrate Antigen Acute Viral Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • M. Sata
    • 1
  • H. Nakano
    • 1
  • T. Hino
    • 1
  • T. Kosedo
    • 2
  • M. Adachi
    • 2
  • K. Tanikawa
    • 1
  1. 1.The Second Department of MedicineKurume University School of MedicineKurume, Fukuoka 830Japan
  2. 2.Japan Immunoresearch LaboratoriesSakae-machi, Takasaki, GunmaJapan

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