The relationship between LeY antigen and the therapeutic efficacy of interferon in chronic hepatitis C
The expression of LeY antigen (Fuc α 1 → 2Gal β 1 → 4 [Fuc α → 3] GlcNAc β 1 → R), recognized by the monoclonal antibody BM-1, was studied in peripheral blood T-lymphocyte subpopulations in patients with viral hepatitis, and in liver tissue of patients with acute viral hepatitis. The relationship between the expression of LeY antigen on peripheral blood T-lymphocytes and the effects of interferon (IFN) therapy for chronic hepatitis type C were also evaluated. LeY antigen is not markedly expressed in B or T-lymphocytes of healthy individuals. However, it was strongly expressed in CD8 and CD4 T-lymphocytes in patients with viral hepatitis. In the acute phase of acute viral hepatitis, the expression of LeY antigen was more markedly expressed on peripheral CD8 T-lymphocytes than on CD4 T-lymphocytes. In chronic hepatitis type B and type C, it was significantly expressed more often on CD4 T-lymphocytes. In the liver tissues of patients with acute viral hepatitis, LeY antigen was expressed on hepatocytes and infiltrating lymphocytes. IFN therapy for chronic active hepatitis type C proved most effective when LeY antigen was more markedly expressed on the patient’s CD4 and CD8 peripheral blood T-lymphocytes before treatment. Further studies are needed to clarify the relationship between the mechanisms of hepatic cell injury and LeY antigen.
KeywordsChronic Hepatitis Acute Hepatitis Acquire Immune Deficiency Syndrome Carbohydrate Antigen Acute Viral Hepatitis
Unable to display preview. Download preview PDF.
- 2.Adachi M, Hayami M, Kashiwagi N, Mizuta T, Ohta Y, Gill MJ, Matheson DS, Tamaoki T, Shiozawa C, Hakomori S (1988) Expression of LeY antigen in human immunodeficiency virus-infected human T cell lines and in peripheral lymphocytes of patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex ( ARC ). J Exp Med 167: 323–331PubMedCrossRefGoogle Scholar
- 7.Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahane Y, Sugai Y, Tanaka T, Sato K, Tuda F, Miyakawa Y, Mayumi M (1992) Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infections sources. J Gen Viol 73: 673–679CrossRefGoogle Scholar