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Role of IgM antibody to hepatitis B core antigen in the diagnosis of hepatitis B exacerbations

  • G. Colloredo Mels
  • G. Bellati
  • G. Leandro
  • Maurizia Rossana Brunetto
  • O. Vicari
  • P. Piantino
  • M. Borzio
  • G. Angeli
  • G. Ideo
  • F. Bonino
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 8)

Summary

IgM anti-HBc levels were measured by the IMx Core-M Abbott assay in 939 serum samples in order to define a specific and sensitive cut-off value for diagnosis of chronic hepatitis B. The sera used were obtained from 52 chronic HBV patients and 10 HBV carriers with HCV or HDV co-infections and 155 asymptomatic subjects without evidence of liver disease. A Youden index value of 95.4% with 98% sensitivity and 97.4% specificity was obtained for an IMx Index value of 0.204 as cut-off. A one-year follow-up study with monthly tests has shown that quantitative analysis of IgM anti-HBc can serve as a non-invasive tool for monitoring HBV infection, and provides an accurate diagnosis of hepatitis B exacerbations. Significant elevations of IgM anti-HBc levels were associated with hepatitis B excerbations in 96.2% of the cases but with none of the ALT flare-ups observed in HCV or HDV infected individuals. These results suggest that quantitative analysis of IgM anti-HBc provides the highest degree of confidence in definition of spontaneous and therapy-induced exacerbations or remissions of hepatitis B.

Keywords

Chronic Hepatitis Core Antigen Chronic Type Chronic Persistent Hepatitis Chronic HBsAg Carrier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • G. Colloredo Mels
    • 1
  • G. Bellati
    • 5
  • G. Leandro
    • 2
  • Maurizia Rossana Brunetto
    • 6
    • 7
  • O. Vicari
    • 4
  • P. Piantino
    • 6
    • 7
  • M. Borzio
    • 3
  • G. Angeli
    • 1
  • G. Ideo
    • 5
  • F. Bonino
    • 6
    • 7
  1. 1.Department of Internal MedicineBolognini HospitalSeriate, BergamoItaly
  2. 2.Department of Internal Medicine Saverio De Bellis HospitalIRCCSCastellana Grotte, BariItaly
  3. 3.Department of Internal MedicineFatebenefratelli HospitalMilanoItaly
  4. 4.Department of Internal Medicine of the Transfusion CenterOOMM HospitalBergamoItaly
  5. 5.Department of Internal Medicine of the Hepatology Center “Crespi”Niguarda HospitalMilanoItaly
  6. 6.Department of Internal MedicineMolinette HospitalTorinoItaly
  7. 7.Laboratory of the Department of GastroenterologyMolinette HospitalTorinoItaly

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