Summary
These studies assessed whether the serum expression of preS1 antigen could be a useful HBV marker for monitoring the progress of antiviral therapy in the treatment of chronic active hepatitis B (CAH-B) virus infections. Our findings indicate that: 1) the rearrangements we observed in the preS region of mutated HBV DNA molecules during chronic infection did not effect the preS1 sequence (21–47) critical for HBV infectivity; 2) the persistence or even the rebound of preS1 antigen expression during follow-up in responders to antiviral therapy may indicate virus persistence, suggesting the possibility of relapse through wild-type HBV or the emergence of HBV variants following the immunoelimination phase.
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References
Petit MA, Dubanchet S, Capel F (1989) A monoclonal antibody specific for the hepatocyte receptor binding site on hepatitis B virus. Mol Immunol 26: 531–537
Petit MA, Strick N, Dubanchet S, Capel F, Neurath AR (1991) Inhibitory activity of monoclonal antibody F35.25 on the interaction between hepatocytes (HepG2 cells) and preSl-specific ligands. Mol Immunol 28: 517–521
Petit MA, Capel F, Dubanchet S, Mabit H (1992) PreSl-specific binding proteins as potential receptors for hepatitis B virus in human hepatocytes. Virology 187: 211–222
Petit MA, Zoulim F, Capel F, Dubanchet S, Dauguet C, Trepo C (1990) Variable expression of preSl antigen in serum during chronic hepatitis B virus infection: an accurate marker for the level of hepatitis B virus replication. Hepatology 11: 809–814
Petit MA, Capel F, Zoulim F, Dubanchet S, Chemin I, Penna A, Ferrari C, Trepo C (1992) PreS antigen expression and anti-preS response in hepatitis B virus infections: relationship to serum HBV DNA, intrahepatic HBcAg, liver damage and specific T-cell response. Arch Virol [Suppl] 4: 105–112
Brunetto MR, Giarin M, Oliveri F, Saracco G, Barbera C, Parrella T, Abate ML, Chiaberge L, Calvo PL, Manzini P, Verme G, Bonino F (1991) “e” Antigen defective hepatitis B virus and course of chronic infection. J Hepatol [Suppl] 13: S82–S86
Gerken G, Kremsdorf D, Capel F, Petit MA, Dauguet C, Manns MP, Meyer Zum Buschenfelde KH, Bréchot C (1991) Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection. Virology 183: 555–565
Tran A, Kremsdorf D, Capel F, Housset C, Dauguet C, Petit MA, Bréchot C (1991) Emergence of and takeover by hepatitis B virus ( HBV) with rearrangements in the preS/S and preC/C genes during chronic HBV infection. J Virol 65: 3566–3574
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© 1993 Springer-Verlag
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Petit, MA., Capel, F., Gerken, G., Dubanchet, S., Bréchot, C., Trépo, C. (1993). Significance and relevance of serum preS1 antigen detection in wild-type and variant hepatitis B virus (HBV) infections. In: Gerlich, W.H. (eds) Research in Chronic Viral Hepatitis. Archives of Virology Supplementum, vol 8. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9312-9_18
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DOI: https://doi.org/10.1007/978-3-7091-9312-9_18
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82497-9
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