Hepatitis B virus C-gene variants

  • S. Miska
  • H. Will
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 8)


The heterogeneity of hepatitis B virus (HBV) is increasingly believed to play a role in viral persistence, pathogenesis, and the type of response to antiviral therapy. One of the best studied parts of the HBV genome is the C-gene which codes for the nucleocapsid protein (HBc) and the e-antigen (HBeAg). Here we attempt to review the recent data on the sequence heterogeneity of this region and its possible implications.


Fulminant Hepatitis Chronic Carrier Woodchuck Hepatitis Virus Encapsidation Signal Initiation Codon Mutation 
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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • S. Miska
    • 1
  • H. Will
    • 1
  1. 1.Heinrich-Pette-Institut für Experimentelle Virologie und ImmunologieUniversität HamburgHamburgFederal Republic of Germany

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