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Implications of genetic variation on the pathogenesis of hepatitis B virus infection

  • Conference paper
Research in Chronic Viral Hepatitis

Part of the book series: Archives of Virology Supplementum ((ARCHIVES SUPPL,volume 8))

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Abstract

It is now well established that sequence variation of hepatitis B virus (HBV) occurs worldwide. Although variants have been classified into subtypes by means of antigenic specificities of the surface proteins, it may be that HBV can be better classified into genotypes by means of percentage nucleotide difference. HBV can be classified into at least four genotypes based on a divergence of >7% at the nucleotide level [1] and it is clear that, based on this definition, other genotypes will be described in the future. Whether genotyping in this fashion is a satisfactory method of classifying HBV, and whether this has any relevance to the pathogenesis of the liver disease, infectivity or spread remains to be seen. Subtypes, defined by antigens associated with specific amino acid changes, are distributed geographically and have no apparent ink with disease. Whether one subtype can infect a person previously infected with a different subtype is unclear; at least, it would seem to be quite uncommon.

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Author information

Authors and Affiliations

  1. Institute of Virology, University of Glasgow, Church Street, Glasgow, G11 5JR, Scotland, UK

    Dr. W. F. Carman

  2. Department of Medicine, St Mary’s Hospital Medical School, London, UK

    H. C. Thomas

  3. Imperial College of Science, Technology and Medicine, London, UK

    H. C. Thomas

Authors
  1. Dr. W. F. Carman
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  2. H. C. Thomas
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Editors and Affiliations

  1. Institut für Medizinische Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany

    W. H. Gerlich

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© 1993 Springer-Verlag

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Carman, W.F., Thomas, H.C. (1993). Implications of genetic variation on the pathogenesis of hepatitis B virus infection. In: Gerlich, W.H. (eds) Research in Chronic Viral Hepatitis. Archives of Virology Supplementum, vol 8. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9312-9_15

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  • DOI: https://doi.org/10.1007/978-3-7091-9312-9_15

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82497-9

  • Online ISBN: 978-3-7091-9312-9

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