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Cell mediated immune response to hepatitis B virus nucleocapsid antigen

  • Conference paper
Research in Chronic Viral Hepatitis

Part of the book series: Archives of Virology Supplementum ((ARCHIVES SUPPL,volume 8))

  • 96 Accesses

Summary

A coordinated and efficient development of humoral and cell-mediated immune responses is believed to be required for complete eradication of viral infections. During the course of hepatitis B virus (HBV) infection, the HLA class II and class I-restricted T cell responses to HBV nucleocapsid antigens are vigorous in patients with acute infection who succeed in clearing the virus but weak or totally absent in patients with chronic persistence of the virus. These findings suggest a role for these responses in the pathogenesis of hepatitis B and in HBV clearance. Molecular analysis of T cell recognition of the HBV nucleoprotein defines the presence of immunodominant core epitopes recognized by helper and cytotoxic T cells that may represent the starting point for the design of alternative strategies for prevention and treatment of HBV infection.

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Author information

Authors and Affiliations

  1. Cattedra Malattie Infettive, Università di Parma, Via Gramsci 14, I-43100, Parma, Italy

    Dr. C. Ferrari, Amalia Penna, A. Bertoletti & F. Fiaccadori

Authors
  1. Dr. C. Ferrari
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  2. Amalia Penna
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  3. A. Bertoletti
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  4. F. Fiaccadori
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Editor information

Editors and Affiliations

  1. Institut für Medizinische Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany

    W. H. Gerlich

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© 1993 Springer-Verlag

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Ferrari, C., Penna, A., Bertoletti, A., Fiaccadori, F. (1993). Cell mediated immune response to hepatitis B virus nucleocapsid antigen. In: Gerlich, W.H. (eds) Research in Chronic Viral Hepatitis. Archives of Virology Supplementum, vol 8. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9312-9_10

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  • DOI: https://doi.org/10.1007/978-3-7091-9312-9_10

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82497-9

  • Online ISBN: 978-3-7091-9312-9

  • eBook Packages: Springer Book Archive

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