Epidemiology of bovine spongiform encephalopathy and related diseases

  • J. W. Wilesmith
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 7)


The occurrence of bovine spongiform encephalopathy in Great Britain, first detected in 1986, has necessarily stimulated a large research programme. Encompassed in this are studies of the epidemiology of the disease. These commenced in 1987 and are continuing. The ensuing results have been reported and reviewed during the course of the epidemic [13, 17, 20]. This paper provides a brief overview of the results of the epidemiological studies, but concentrates on the more recent features of the epidemic which are important in assessing the future course of the disease.


Bovine Spongiform Encephalopathy Cattle Population Bone Meal Maternal Transmission Veterinary Surgeon 
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  1. 1.
    Bradley R, Matthews D (1992) Sub-acute, transmissible spongiform encephalopathies: current concepts and future needs. Rev Sci Tech Off Int Epiz 11: 605–634Google Scholar
  2. 2.
    Fleetwood AJ, Furley CW (1990) Spongiform encephalopathy in an eland. Vet Rec 126: 408–409PubMedGoogle Scholar
  3. 3.
    Fraser H, McConnell I, Wells GAH, Dawson M (1988) Transmission of bovine spongiform encephalopathy to mice. Vet Rec 123: 472PubMedCrossRefGoogle Scholar
  4. 4.
    Hope J, Reekie LJD, Hunter N, Multhaup G, Beyreuther K, White H, Scott AC, Stack MJ, Dawson M, Wells GAH (1988) Brain fibrils of novel British cattle disease contain scrapie associated protein. Nature 336: 390–392PubMedCrossRefGoogle Scholar
  5. 5.
    Jeffrey M, Wells GAH (1988) Spongiform encephalopathy in a nyala ( Tragelaphus angasi ). Vet Pathol 25: 398–399PubMedCrossRefGoogle Scholar
  6. 6.
    Kirkwood JK, Wells GAH, Wilesmith JW, Cunningham AA, Jackson SI (1990) Spongiform encephalopathy in an Arabian oryx (Oryx leucoryx) and a greater kudu (Tragelaphus strepsiceros). Vet Rec 127–420Google Scholar
  7. 7.
    Kirkwood JK, Wells GAH, Cunningham AA, Jackson SI, Scott AC, Dawson M, Wilesmith JW (1992) Scrapie-like encephalopathy in greater kudu (Tragelaphus strepsiceros): morbidity in an index case offspring without dietary exposure to ruminant derived protein. Vet Rec 130: 365–367PubMedCrossRefGoogle Scholar
  8. 8.
    Leggett MM, Dukes J, Pixie HM (1990) A spongiform encephalopathy in a cat. Vet Rec 127: 586–588PubMedGoogle Scholar
  9. 9.
    Order (1990) The bovine spongiform encephalopathy (No 2) (Amendment) Order 1990. Statutory Instrument 1990, No 1930. HMSO, LondonGoogle Scholar
  10. 10.
    Peet RL, Curran JM (1992) Spongiform encephalopathy in an imported cheetah ( Acinoryx jubatus ). Aust Vet J 69: 171PubMedCrossRefGoogle Scholar
  11. 11.
    Wells GAH, Scott AC, Johnson CT, Gunning RF, Hancock RD, Jeffrey M, Dawson M, Bradley R (1987) A novel progressive spongiform encephalopathy in cattle. Vet Rec 121: 419–420PubMedCrossRefGoogle Scholar
  12. 12.
    Wilesmith JW (1991) Bovine spongiform encephalopathy: epidemiological approaches, trials and tribulations. In: Proceedings of the sixth international symposium on veterinary epidemiology and economics, pp 32–43Google Scholar
  13. 13.
    Wilesmith JW (1992) Epidemiology of bovine spongiform encephalopathy. Semin Virol 2: 239–245Google Scholar
  14. 14.
    Wilesmith JW, Ryan JBM (1992) Bovine spongiform encephalopathy: recent observations on the age-specific incidences. Vet Rec 130: 491–492PubMedCrossRefGoogle Scholar
  15. 15.
    Wilesmith JW, Ryan JBM, Atkinson MJ (1991) Bovine spongiform encephalopathy: epidemiological studies on the origin. Vet Rec 128: 199–203PubMedCrossRefGoogle Scholar
  16. 16.
    Wilesmith JW, Ryan JBM, Hueston WD (1992) Bovine spongiform encephalopathy: case-control studies of calf feeding practices and meat and bone meal inclusion in proprietary concentrates. Res Vet Sci 52: 325–331PubMedCrossRefGoogle Scholar
  17. 17.
    Wilesmith JW, Ryan JBM, Hueston WD, Hoinville LJ (1992) Bovine spongiform encephalopathy: descriptive epidemiological features 1985–1990. Vet Rec 130: 90–94PubMedCrossRefGoogle Scholar
  18. 18.
    Wilesmith JW, Hoinville LJ, Ryan JBM, Sayers AR (1992) Bovine spongiform encephalopathy: aspects of the clinical picture and analyses of possible changes 1986–1990. Vet Rec 130: 197–201PubMedCrossRefGoogle Scholar
  19. 19.
    Wilesmith JW, Wells GAH (1991) Bovine spongiform encephalopathy. Curr Top Microbiol Immunol 172: 21–38PubMedCrossRefGoogle Scholar
  20. 20.
    Wilesmith JW, Wells GAH, Cranwell MP, Ryan JBM (1988) Bovine spongiform encephalopathy: epidemiological studies. Vet Rec 123: 638–644PubMedGoogle Scholar
  21. 21.
    Willoughby K, Kelly DF, Lyon DG, Wells GAH (1992) Spongiform encephalopathy in a captive puma ( Felis concolor ). Vet Rec 131: 431–434PubMedCrossRefGoogle Scholar
  22. 22.
    Wyatt JM, Pearson GR, Smerdon TN, Gruffyd-Jones TJ, Wells GAH (1990) Spongiform encephalopathy in a cat. Vet Rec 126: 513Google Scholar
  23. 23.
    Wyatt JM, Pearson GR, Smerdon TN, Gruffyd-Jones TJ, Wells GAH, Wilesmith JW (1991) Naturally occurring scrapie-like spongiform encephalopathy in five domestic cats. Vet Rec 129: 233–236PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • J. W. Wilesmith
    • 1
    • 2
  1. 1.Epidemiology DepartmentCentral Veterinary LaboratoryNew Haw, Addlestone, SurreyUK
  2. 2.Epidemiology DepartmentCentral Veterinary LaboratoryNew Haw, Addlestone, SurreyUK

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