Borna Disease virus infection and affective disorders in man

  • L. Bode
  • R. Ferszt
  • G. Czech
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 7)


Borna Disease virus (BDV) can persistently infect the central nervous system of a broad spectrum of animal species. The clinical course varies from slight behavioral disturbancies to a fatal neurological syndrome. In-vivo diagnosis is based on the strong humoral immune response to BDV antigens. Since also human infections could be confirmed by specific antibodies and increased seroprevalence was found in patients with chronic neurologic or immunologic disorders, the contribution of BDV or a BDV-like human variant to syndromes with yet unknown etiology became of great interest. We presented the first data of a current follow-up study on 70 psychiatric patients who were tested three times each after hospitalization. In contrast to previously found low prevalence of antibody carriers by screening (2–4%), we now found 20% positives by follow-up testing. Furthermore, of the randomly selected patients with different psychiatric diagnosis, the highest proportion of antibody carriers was detected among patients with major depression (more than 30%), compared to only 8% among patients with dysthymia (neurotic depression). This led us to hypothesize that Bornavirus infection might contribute somehow to the syndrome of major depressive illness by altering neuronal cells in the limbic system.


Chronic Fatigue Syndrome Psychiatric Patient Antibody Prevalence Paranoid Psychosis Neurotic Depression 


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  1. 1.
    Bechter K, Herzog S, Fleischer B, Schüttler R, Rott R (1987) Kernspintomographische Befunde bei psychiatrischen Patienten mit und ohne Serum-Antikörper gegen das Virus der Bornaschen Krankheit. Nervenarzt 58: 617–624PubMedGoogle Scholar
  2. 2.
    Bleuler E (1983) Lehrbuch der Psychiatrie, 15th edn. Springer, Berlin Heidelberg New York Tokyo, pp 485–486CrossRefGoogle Scholar
  3. 3.
    Bode L, Riegel S, Ludwig H, Amsterdam JD, Lange W, Koprowski H (1988) Borna Disease virus-specific antibodies in patients with HIV infection and with mental disorders. Lancet ii: 689Google Scholar
  4. 4.
    Bode L, Querfurth H, Ferszt R, Gosztonyi G, Rigas N, Czech G, Ludwig H (1991) Antibodies to Borna disease virus are four times as frequent in depressives as in controls. In: Wissenschaftswoche 1991, Forschungsprojekte am Klinikum Steglitz, Freie Universität Berlin, pp 269–271Google Scholar
  5. 5.
    Bode L, Czech G, Ferszt R, Ludwig H (1992) Bornavirus-Infektion beim Menschen: eine neue Zoonose? In: Bericht des 4. Hohenheimer Seminars “Aktuelle Zoonosen”, September 16–17, 1992, Stuttgart. Deutsche Veterinärmedizinische Gesellschaft (DVG), Giessen, pp 138–147Google Scholar
  6. 6.
    Bode L, Riegel S, Lange W, Ludwig H (1992) Human infections with Borna Disease virus: seroprevalence in patients with chronic diseases and healthy individuals. J Med Virol 36: 309–315PubMedCrossRefGoogle Scholar
  7. 6a.
    Bode L, Komaroff AL, Ludwig H (1992) No serologic evidence of Borna Disease virus in patients with Chronic Fatigue Syndrome ( CSF ). Clin Infect Dis 15: 1049PubMedCrossRefGoogle Scholar
  8. 7.
    Briese T, de la Torre JC, Lewis A, Ludwig H, Lipkin WI (1992) Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells. Proc Natl Acad Sci Neurobiol USA 89: 11486–11489CrossRefGoogle Scholar
  9. 8.
    Dittrich W, Bode L, Ludwig H, Kao M, Schneider K (1989) Learning deficiencies in Borna Disease virus-infected but clinically healthy rats. Biol Psychiatry 26: 818–828PubMedCrossRefGoogle Scholar
  10. 9.
    Gosztonyi G, Ludwig H (1984) Neurotransmitter receptors and viral neurotropism. Neurophysiol Clin 3: 107–114Google Scholar
  11. 10.
    Hirano N, Kao M, Ludwig H (1983) Persistent, tolerant or subacute infection in Borna disease virus infected rats. J Gen Virol 64: 1521–1530PubMedCrossRefGoogle Scholar
  12. 11.
    Lipkin WI, Travis GH, Carbone KM, Wilson MC (1990) Isolation and characterization of Borna disease agent cDNA clones. Proc Natl Acad Sci USA 87: 4184–4188PubMedCrossRefGoogle Scholar
  13. 12.
    Ludwig H, Bode L, Gosztonyi G (1988) Borna Disease: a persistent virus infection of the central nervous system. Prog Med Virol 35: 107–151PubMedGoogle Scholar
  14. 13.
    Narayan O, Herzog S, Frese K, Scheefers H, Rott R (1983) Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis 148: 305–315PubMedCrossRefGoogle Scholar
  15. 14.
    Rott R, Herzog S, Fleischer B, Winokur H, Amsterdam JD, Dyson W, Koprowski H (1985) Detection of serum antibodies to Borna Disease virus in patients with psychiatric disorders. Science 228: 755–756PubMedCrossRefGoogle Scholar
  16. 15.
    Vande Woude S, Richt JA, Zink MC, Rott R, Narayan O, Clements JE (1990) A Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science 250: 1278–1281CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • L. Bode
    • 1
    • 4
  • R. Ferszt
    • 2
  • G. Czech
    • 3
  1. 1.Robert Koch-Institute, Department of VirologyFree University BerlinBerlinFederal Republic of Germany
  2. 2.Klinikum Steglitz, Department of PsychiatryFree University BerlinBerlinFederal Republic of Germany
  3. 3.Institute of VirologyFree University BerlinBerlinFederal Republic of Germany
  4. 4.Abteilung VirologieRobert Koch-Institut des BundesgesundheitsamtesBerlinFederal Republic of Germany

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