Stability of attenuated poliovirus strain genotypes in the human intestinal tract

  • P. Minor
  • G. Dunn
  • J. W. Almond
  • A. Macadam


The major part of the attenuation of the live poliovirus vaccine strains of Sabin is attributable to differences from virulent strains at two or three bases. The mutations revert or are suppressed by second site mutations in vaccine recipients with varying degrees of rapidity and to varying extents, employing both point mutation and recombination. Despite the high degree of genetic variability of the virus, vaccine associated paralysis is very rare.


Vaccine Strain Oral Poliovirus Vaccine Oral Poliovaccine Post Immunisation Paralytic Poliomyelitis 
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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • P. Minor
    • 1
  • G. Dunn
    • 1
  • J. W. Almond
    • 2
  • A. Macadam
    • 1
  1. 1.National Institute for Biological Standards and ControlSouth Mimms, Potters Bar, HertsUK
  2. 2.University of ReadingWhitenightsUK

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