Studies aiming at improvement of inactivated poliovirus vaccine preparations
It has been known for some time that inactivated poliovirus vaccine (IPV), including the recently introduced enhanced-potency preparations, in spite of inducing very high levels of neutralizing and probably protecting serum antibodies are inferior to oral poliovirus vaccine (OPV) in preventing intestinal poliovirus infection in the vaccinees. We have proposed that this deficiency, at least as regards type 3 poliovirus, is based on different antigenic sites involved in the induction of antibodies by the two different vaccines because of proteolytic cleavage of a major antigenic site during infection. An approach to circumvent this problem comprises modification of the type 3 component of IPV with trypsin before immunization. A pilot vac cine prepared according to this principle has been obtained and its clinical evaluation will be started soon.
KeywordsCapsid Protein Antigenic Site Oral Poliovirus Vaccine Poliovirus Type Intact Virus
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