Immunogenicity of poliovirus vaccines with special reference to the choice between oral and inactivated vaccines in developing countries
Both inactivated and oral poliovirus vaccines have successfully eradicated poliomyelitis in the developed world. Inactivated vaccine may appear to have some advantages for the developing world, particularly with regard to interference and greater stability, but fails to address the major reservoir of faecal-orally spread virus, the gastrointestinal tract. Inactivated vaccine used to supplement oral vaccine schedules increases cost and could cause confusion in adminis tration. Interference in oral vaccine schedules could be addressed by a supplementary neonatal dose. In most of Africa, type 1 poliovirus is the dominant endemic strain and also the cause of outbreaks, and neonatal supplementation with type 1 would have particular advantages.
KeywordsVaccine Coverage Oral Poliovirus Vaccine Population Immunity Inactivate Poliovirus Vaccine Paralytic Poliomyelitis
Unable to display preview. Download preview PDF.
- 6.World Health Organizaiton (1989) Expanded Programme on Immunization (EPI). Poliomyelitis in 1986,1987 and 1988, Part I. Wkly Epidem Rec 64: 273–279Google Scholar
- 7.Sutter RW, Patriarca PA, Brogan S, Malankar PG, Pallansch MA, Kew OM, Bass AG, Cochi SL, Alexander JP, Hall DB, Suleiman AJM, Al-Ghassany AAK, El-Bualy MS (1991) Outbreak of paralytic poliomyelitis in Oman: evidence for widespread transmission among fully vaccinated children. Lancet 338: 715–720PubMedCrossRefGoogle Scholar
- 10.World Health Organization (1984) Poliomyelitis outbreak in Israel. Wkly Epidem Rec 63:325–326Google Scholar
- 12.Department of National Health, South Africa (1990) The six vaccine-preventable diseases. Epidem Comments 17: 3–19Google Scholar
- 14.World Health Organization Expanded Programme on Immunization (1985) Global advisory group. Wkly Epidem Rec 60: 13–16Google Scholar