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Cell-mediated immune response to measles virus

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Measles and Poliomyelitis

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Summary

Measles virus (MV) causes a strong but temporary depression of cell-mediated immunity (CMI) in infected individuals Despite of the immunosuppression, both proliferative and cytotoxic T cell responses appear after MV infection. CMI response develops slowly, reaches only a relatively low level, and wanes rapidly afterwards. Memory T cells are maintained a long time after measles. The major structural MV proteins are recognized by T cells immune individuals but the role of nonstructural MV proteins has not been clarified. A few T cell epitopes have been described on the internal protein N and the envelope proteins F and H but their importance in the protective immune response has not been shown. The major class of cytotoxic T cells are CD8 positive, MHC-class I restricted, but CD4 positive, class II restricted cytotoxic T cells have also been described.

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Authors and Affiliations

  1. Department of Virology, University of Turku, Turku, Finland

    A. A. Salmi

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  1. A. A. Salmi
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Editors and Affiliations

  1. Faculty of Medicine, University of Montreal, Montreal, Canada

    Edouard Kurstak (President - International Comparative Virology Organization, Member - Viral Diseases Panel, World Health Organization) (President - International Comparative Virology Organization, Member - Viral Diseases Panel, World Health Organization)

  2. International Comparative Virology Organization, Montreal, Canada

    Edouard Kurstak (President - International Comparative Virology Organization, Member - Viral Diseases Panel, World Health Organization) (President - International Comparative Virology Organization, Member - Viral Diseases Panel, World Health Organization)

  3. Medical Research Centre, King Fahad Hospital, Riyadh, Saudi Arabia

    Edouard Kurstak (President - International Comparative Virology Organization, Member - Viral Diseases Panel, World Health Organization) (President - International Comparative Virology Organization, Member - Viral Diseases Panel, World Health Organization)

  4. Viral Diseases Panel, World Health Organization, Geneva, Switzerland

    Edouard Kurstak (President - International Comparative Virology Organization, Member - Viral Diseases Panel, World Health Organization) (President - International Comparative Virology Organization, Member - Viral Diseases Panel, World Health Organization)

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© 1993 Springer-Verlag/Wien

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Salmi, A.A. (1993). Cell-mediated immune response to measles virus. In: Kurstak, E. (eds) Measles and Poliomyelitis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9278-8_14

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  • DOI: https://doi.org/10.1007/978-3-7091-9278-8_14

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82436-8

  • Online ISBN: 978-3-7091-9278-8

  • eBook Packages: Springer Book Archive

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