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Cell-mediated immune response to measles virus

  • A. A. Salmi

Summary

Measles virus (MV) causes a strong but temporary depression of cell-mediated immunity (CMI) in infected individuals Despite of the immunosuppression, both proliferative and cytotoxic T cell responses appear after MV infection. CMI response develops slowly, reaches only a relatively low level, and wanes rapidly afterwards. Memory T cells are maintained a long time after measles. The major structural MV proteins are recognized by T cells immune individuals but the role of nonstructural MV proteins has not been clarified. A few T cell epitopes have been described on the internal protein N and the envelope proteins F and H but their importance in the protective immune response has not been shown. The major class of cytotoxic T cells are CD8 positive, MHC-class I restricted, but CD4 positive, class II restricted cytotoxic T cells have also been described.

Keywords

Multiple Sclerosis Patient Cell Epitope Measle Virus Measle Infection Immune Individual 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • A. A. Salmi
    • 1
  1. 1.Department of VirologyUniversity of TurkuTurkuFinland

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