Cell-mediated immune response to measles virus
Measles virus (MV) causes a strong but temporary depression of cell-mediated immunity (CMI) in infected individuals Despite of the immunosuppression, both proliferative and cytotoxic T cell responses appear after MV infection. CMI response develops slowly, reaches only a relatively low level, and wanes rapidly afterwards. Memory T cells are maintained a long time after measles. The major structural MV proteins are recognized by T cells immune individuals but the role of nonstructural MV proteins has not been clarified. A few T cell epitopes have been described on the internal protein N and the envelope proteins F and H but their importance in the protective immune response has not been shown. The major class of cytotoxic T cells are CD8 positive, MHC-class I restricted, but CD4 positive, class II restricted cytotoxic T cells have also been described.
KeywordsMultiple Sclerosis Patient Cell Epitope Measle Virus Measle Infection Immune Individual
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- 16.IlonenJ (1979) Lymphocyte blast transformation response of seropositive and seronegative subjects to herpes simplex ,rubella ,mumps ,and measles virus antigens. Acta Pathol Microbiol Scand C 87: 151–157Google Scholar
- 49.Ward BJ, Johnson RT, Vaisberg A, Jauregui E, Griffin DE (1990) Spontaneous proliferation of peripheral mononuclear cells in natural measles virus infection: identifi cation of dividing cells and correlation with mitogen responsiveness. Clin Immunol Immunopathol 55: 315–326PubMedCrossRefGoogle Scholar