Cell-mediated immune response to measles virus

  • A. A. Salmi


Measles virus (MV) causes a strong but temporary depression of cell-mediated immunity (CMI) in infected individuals Despite of the immunosuppression, both proliferative and cytotoxic T cell responses appear after MV infection. CMI response develops slowly, reaches only a relatively low level, and wanes rapidly afterwards. Memory T cells are maintained a long time after measles. The major structural MV proteins are recognized by T cells immune individuals but the role of nonstructural MV proteins has not been clarified. A few T cell epitopes have been described on the internal protein N and the envelope proteins F and H but their importance in the protective immune response has not been shown. The major class of cytotoxic T cells are CD8 positive, MHC-class I restricted, but CD4 positive, class II restricted cytotoxic T cells have also been described.


Multiple Sclerosis Patient Cell Epitope Measle Virus Measle Infection Immune Individual 
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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • A. A. Salmi
    • 1
  1. 1.Department of VirologyUniversity of TurkuTurkuFinland

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