A new and critical view of isobolograms
Isobolograms have been mentioned throughout the foregoing chapters. Indeed, this graphical presentation of effects in combination is widely used since Loewe and Muischnek (1926) suggested it for the analysis of combined effects in pharmacology and toxicology. There are a number of objections to the general use of isobolograms, which in part have been touched in the foregoing chapters. However, many investigators consider the isobologram method as “the method of choice for the evaluation of possible interaction between biologically active agents” (e.g., Sühnel 1992). Given the popularity of these graphs, it appears important to look at isobolograms from a critical point of view.
KeywordsIndependent Effect Graphical Presentation Combination Index Additive Dose Critical View
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