Synergism/potentiation and antagonism — phenomena and mechanisms
This chapter describes and discusses the differentiation and quantitation of combined effects with respect to synergism or potentiation on the one hand, and antagonism on the other, in complex interactions. In the combinations considered here, the agents exhibit effects in the same direction, when tested singly. Hence, in binary mixtures, both compounds are active. This is the situation which most researchers associate with the expression of “combined effects”.
KeywordsIndependent Effect Total Effect Combination Index Independent Action Effect Approach
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