Synergism/potentiation and antagonism — phenomena and mechanisms

  • Gerald Pöch


This chapter describes and discusses the differentiation and quantitation of combined effects with respect to synergism or potentiation on the one hand, and antagonism on the other, in complex interactions. In the combinations considered here, the agents exhibit effects in the same direction, when tested singly. Hence, in binary mixtures, both compounds are active. This is the situation which most researchers associate with the expression of “combined effects”.


Independent Effect Total Effect Combination Index Independent Action Effect Approach 


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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • Gerald Pöch
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieUniversität GrazGrazAustria

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