Concepts and models of interactions — additivity and independence
This chapter deals with the two most important models of combined effects of two substances, in which the latter phenomenologically and qualitatively exhibit the same effect. These models are based on different concepts. In one model, the combined effect of A and B is explained by the concept that B behaves like a dose of A (and, consequently, vice versa), and in the other that the response to A is independent of B (and vice versa). When observed combined effects correspond to one or the other model, we can first interpret the phenomenon itself on the basis of the model. Secondly, we can draw conclusions with respect to the underlying mechanism. To aid understanding, an overview is given in Table 1, which is explained in the following sections.
KeywordsCombine Effect Partial Agonist Competitive Interaction Additive Interaction Independent Action
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