The molecular biology of the slow viruses

  • Pawel P. Liberski
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 6)


All viruses, and there is no exception to this claim, contain nucleic acid — DNA or RNA enveloped with several proteins. The smallest infectious agents, plant viroids contain only RNA and not proteins [287, 288]. The scrapie virus (and analogously, viruses of CJD and the other spongiform ancephalopathies) seems to be that exception (at least several investigators believe it) in so far that the infection-specific nucleic acid has not been found. In this chapter I will review all efforts to isolate infection-specific nucleic acid from scrapie- and CJD-affected brains and spleens, unsuccessful to date and more than often misleading.


Prion Protein Bovine Spongiform Encephalopathy Potato Spindle Tuber Viroid Scrapie Agent Scrapie Infectivity 
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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • Pawel P. Liberski
    • 1
  1. 1.Electron Microscopic Laboratory, Department of OncologyMedical Academy LodzŁodzPoland

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