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Erhöhter Lysophosphatidylcholingehalt in Thrombozytenmembranen bei schizophrenen Patienten

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Biologische Psychiatrie der Gegenwart

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Zusammenfassung

Vor kurzem konnten wir einen Unterschied in der Aktivität des die Phospholipide abbauenden Enzyms Phospholipase A2 (PLA2) feststellen. Wir fanden signifikant höhere Aktivitäten in Plasma, Serum und Thrombozyten schizophrener Patienten, verglichen mit gesunden Kontrollpersonen und nicht-schizophrenen psychiatrischen Patienten [5, 6, 7], Das Hauptsubstrat der PLA2 ist Phosphatidylcholin (PC), welches in das hochtoxische Abbauprodukt Lysophosphatidylcholin (LPC) und Arachidonsäure gespalten wird [4, 8].

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Authors and Affiliations

  1. Arbeitsgruppe Neurobiologie der funktionellen Psychosen, Zentralinstitut für Seelische Gesundheit, Postfach 12 21 20, D-68072, Mannheim, Bundesrepublik Deutschland

    Dr. A. Steudle, A. M. Pangerl & W. F. Gattaz

Authors
  1. Dr. A. Steudle
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  2. A. M. Pangerl
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  3. W. F. Gattaz
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Editor information

Editors and Affiliations

  1. Département Universitaire de Psychiatrie Adultes (DUPA), Route de Cery, CH-1008, Prilly-Lausanne, Switzerland

    Pierre Baumann

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© 1993 Springer-Verlag Wien

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Steudle, A., Pangerl, A.M., Gattaz, W.F. (1993). Erhöhter Lysophosphatidylcholingehalt in Thrombozytenmembranen bei schizophrenen Patienten. In: Baumann, P. (eds) Biologische Psychiatrie der Gegenwart. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9263-4_6

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  • DOI: https://doi.org/10.1007/978-3-7091-9263-4_6

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9264-1

  • Online ISBN: 978-3-7091-9263-4

  • eBook Packages: Springer Book Archive

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