Investigations of the experiment “MIRGEN” were aimed at the evaluation of effects of space flight, like ionising radiation, microgravity or stress, on possible modifications of genetic information. Chemicals, environmental pollution, ionising radiation are known to damage DNA (=deoxyribonucleic acid). Cells normally recognize genetic damage and eliminate modifications within their genetic information by various DNA repair processes. DNA damage not removed by cellular enzymes can lead to impairment of metabolic processes, disturbance in DNA synthesis, cell cycle and differentiation. Late effects of DNA damage may result in tumorigenesis and inherited genetic diseases.
KeywordsSpace Flight Sister Chromatid Exchange Sedimentation Profile Sampling Term Mitogen Stimulate Lymphocyte
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