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Abstract

The taxane diterpenoids form a unique class of natural products containing the unusual taxane skeleton (1.1) or closely related skeletons and occurring in various members of the genus Taxus (Taxaceae) and closely related genera. Initial interest in the constituents of Taxus species was sparked by the known toxicity of T. baccata, or the English yew, since human fatalities due to ingestion of this plant were recorded as long ago as the first century B.C.. Thus Julius Caesar, speaking of his wars against the Gallic tribes, writes “Catuvolcus, who was king of half of the Eburones and had joined Ambiorix in the conspiracy, was now old and weak, unable to endure the hardships of war or flight. He solemnly cursed Ambiorix for instigating the conspiracy, and then poisoned himself with yew, a tree which is very common in Gaul and in Germany” (27).

Keywords

Exocyclic Double Bond Taxus Species Ester Side Chain Taxol Content Oxetane Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1993

Authors and Affiliations

  • D. G. I. Kingston
    • 1
  • A. A. Molinero
    • 1
  • J. M. Rimoldi
    • 1
  1. 1.Department of ChemistryVirginia Polytechnic Institute and State UniversityBlacksburgUSA

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