Skip to main content
SpringerLink
Log in

Prevention of Post-Traumatic Excitotoxic Brain Damage with NMDA Antagonist Drugs: A New Strategy for the Nineties

  • Conference paper
Neurotraumatology: Progress and Perspectives

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 55))

  • 64 Accesses

Summary

Excitotoxic mechanisms due to overactivity of the amino acid neurotransmitters glutamate and aspartate maybe responsible for brain damage after injury. In this review we examine ischaemia and shear injury, which are relevant to human head injury. The opportunities for treatment using glutamate antagonist drugs are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson KJ, Monaghan DT, Bridges RJ, Travoularis AL, Cotman CW (1990) Autoradiographic characterisation of putative excitatory amino acid transport sites. Neuroscience 38: 311–322

    Article  PubMed  CAS  Google Scholar 

  2. Becker DP, Katayama Y, Tamura T, Gorman L, Cheung MK (1989) Excitatotoxic ionic fluxes and neuronal dysfunction following traumatic brain injury. J Cereb Blood Flow Metabol 9: 1: S302

    Google Scholar 

  3. Benveniste H, Drejer J, Schousboe A, Diemer H (1984) Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient global cerebral ischaemia monitored by intracerebral microdualysis. J Neurochem 43: 1369–1374

    Article  PubMed  CAS  Google Scholar 

  4. Blumberg PC, Jones NR, North JB (1989) Diffuse axonal injury in head trauma. J Neurol Neurosurg Psychiatry 52 (7): 838–842

    Article  Google Scholar 

  5. Bullock R, Butcher SP, Kendall, McCulloch J (in press 1992) Regional cerebral blood flow and extracellular glutamate release after acute subdural hematoma in the rat. J Neurosurg

    Google Scholar 

  6. Bullock R, Statham P, Patterson J, Teasdale GM, Teasdale E, Wyper D (1989) Tomographic mapping of CBF, CBV and blood brain barrier changes in after focal head injury using SPECT: mechanisms for late deterioration. In: Hoff J, Betz AL (eds) Proceedings of VIIth International Symposium on Intracranial Pressure and Brain Injury. Springer, Berlin Heidelberg New York, pp 637–639

    Google Scholar 

  7. Bullock R, Teasdale GM (1990) Head injury and brain ischemia: monitoring and prediction of outcome. In: Siesjo BK, Miller JD (eds) Proceedings of the International Symnposium on Brain Ressuscitation, Yamaguchi, Japan, 1988. Springer

    Google Scholar 

  8. Bullock R, Teasdale GM (1991) Surgical management of traumatic intracranial hematomas. In: Braakman R (ed) Handbook of clinical neurology, Vol 24. Head injury. Elsevier, Amsterdam

    Google Scholar 

  9. Butcher SP, Bullock R, Graham DI, MCCulloch J (1990) Release of neuro-excitatory amino acids from rat brain following middle cerebral artery occlusion. Br J Pharmacol 99: 277

    Google Scholar 

  10. Chen M-H, Bullock R, Teasdale GM, McCulloch J (in press 1992) Effect of glutamate anatgonist on reducing the ischemic damage after subdural hematoma in the rat. J Neurosurg

    Google Scholar 

  11. Choi DW (1990) Cerebral hypoxia: Some new approaches and unanswered questions. J Neurosci 10 (8): 2493–2501

    PubMed  CAS  Google Scholar 

  12. Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7: 369–379

    PubMed  CAS  Google Scholar 

  13. Choi DW, Koh JY, Peters S (1988) Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci 8: 185–196

    PubMed  CAS  Google Scholar 

  14. Cotman C, Monaghan D, Ottersen OP, Storn Mathieson J (1987) Anatomical organisation of excitatory amino acids receptors and their pathways. TINS 10: 273–280

    CAS  Google Scholar 

  15. Gennarelli TA, Segawa H, Wald U, Czernicki Z, Marsh K, Thompson C (1982) Physiological response to angular acceleration of the head. In: Grossman RG, Gildenberg PL (eds) Head injury: basic and clinical aspects. Raven Press, pp 129–139

    Google Scholar 

  16. Ginsberg MD (1990) Glycolytic metabolism in brain ischaemic. In: Weinstein PR, Faden AI (eds) Protection of the brain from ischaemia. Williams and Wilkins, Baltimore

    Google Scholar 

  17. Graham DI, Adams JH, Doyle D (1978) Ischemic brain damage in fatal non-missile head injury. J Neurol Sci 39: 213–234

    Article  PubMed  CAS  Google Scholar 

  18. Graham DI, Ford I, Adams JH, Doyle D, Teasdale G, Lawrence A, McLelland DR (1989) Ischemic brain damage is still common in fatal non-missile head injury. J Neurol Neurosurg Psychiatry 52: 346–350

    Article  PubMed  CAS  Google Scholar 

  19. Graham SH, Shiraishi K, Panter SS, Simon RP, Faden AI (1990) Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia. Neurosci Letter 110: 124–130

    Article  CAS  Google Scholar 

  20. Inglis FM, Bullock R, Chen MH, Graham DI, Miller JD, McCulloch J, Teasdale GM (1990) Ischemic brain damage associated with tissue hypermetabolism in acute subdural haematoma. Reduction by a glutamate anatgonist. In: Reulen HJ, Baethmann A, Fenstermacher J, Marmarou A, Spatz M (eds) Brain Edema VIII. Proceedings of the Eight International Symposium Berne, June 17–20, 1990. Acta Neurochir (Wien) [Suppl] 51: 277–279

    Google Scholar 

  21. Jenkins LW, Lewelt W, Young HF, Clifton GL, Hayes AL (1989) Muscarinic and NMDA receptor blockade attenuates increased post traumatic vulnerability to cerebral ischemia. J CBF Metabol 9: S750

    Google Scholar 

  22. Katayama Y, Cheung MK, Gorman L, Tamura L, Becker DP (1988) Increase in extracellular glutamate and associated massive ion fluxes following concussive brain injury. Neurosci Abstr 14: 1154

    Google Scholar 

  23. Kirino T, Tamura A, Sano K (1984) Delayed neuronal death in the rat hippocampus following transient forebrain ischaemia. Acta Neuropathol (Berl) 64: 139–147

    Article  CAS  Google Scholar 

  24. Lucas DR, Newhouse JP (1957) The toxic effect of sodium L glutamate on the inner layers of the retina. AMA Arch Ophtalmol 58: 193–201

    Article  CAS  Google Scholar 

  25. MacDermott AB, Dale N (1987) Receptors, ino channels and synaptic potentials underlying the integrative actions of excitatory amino acids. TINS 10: 280–283

    CAS  Google Scholar 

  26. Macpherson P, Graham DI (1978) Correlation between angiographic findings and the ischemia of head injury. J Neurol Neurosurg Psychiatry 41: 122–127

    Article  PubMed  CAS  Google Scholar 

  27. Meldrum B (1990) Protection against ischemic neuronal damage by drugs acting on excitatory neurotransmission. Cerebrovasc Brain Metabol Rev 2: 27–57

    CAS  Google Scholar 

  28. Michaels RL, Rothman SM (1990) Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular concentrations. J Neurosci 10: 283–292

    PubMed  CAS  Google Scholar 

  29. Miller JD, Bullock R, Graham DI, Chen M-H, Teasdale G (1990) Ischemic brain damage in a model of acute subdural haematoma. Neurosurgery 27, No. 3: 433–439

    Article  PubMed  CAS  Google Scholar 

  30. Miller JD, Sweet RC, Narayan R, Becker DP (1978) Early insults to the injured brain. JAMA 240: 439–442

    Article  PubMed  CAS  Google Scholar 

  31. Miller JD, Butterworth JF, Oudeman SK, Faulkner JE, Choi SC, Selhoust JB, Harbison J, Lutz HA, Becker DP, Young HF (1981) Further experience with the management of severe head injury. J Neurosurg 54: 289–299

    Article  PubMed  CAS  Google Scholar 

  32. Nichols D, Attwell D (1990) The release and uptake of excitatory amino acids. Trends Pharmacol Sci 11: 462–468.

    Article  Google Scholar 

  33. Panter S, Yum SW, Faden AI (1990) Alteration in extracellular amino acids after traumatic spinal cord injury. Ann Neurol 27: 96–100

    Article  PubMed  CAS  Google Scholar 

  34. Persson L, Hillered L, Ponten U, Ungerstedt (1989) Intracerebral microdialysis for continuous metabolic monitoring of neurosurgical patients: preliminary methodological considerations. J Cereb Blood Flow Metabol 9: S584

    Google Scholar 

  35. Rothman SM, Olney JW (1986) Glutamate and the pathophysiology of hypoxic ischemic brain damage. Ann Neurol 19: 105–111

    Article  PubMed  CAS  Google Scholar 

  36. Simon RP, Shirashi K (1990) N-Methyl-D-Aspartate antagonist reduces stroke size and regional glucose metabolism. Ann Neurol 27: 606–612

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Glasgow, Scotland

    Mr. R. Bullock, Y. Kuroda & G. M. Teasdale

  2. Wellcome Surgical Institute, University of Glasgow, Scotland

    J. Mcculloch

Authors
  1. Mr. R. Bullock
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. M. Teasdale
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Mcculloch
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurophysiology, Hospital Santo Antonio, Porto, Portugal

    A. Martins da Silva

  2. Unit of Human Physiology, Biomedical Institute “Abel Salazar”, University of Porto, Portugal

    A. Martins da Silva

  3. Department of Neurosurgery, Hospital Santo Antonio, Porto, Portugal

    A. Rocha Melo

  4. Neurochirurgische Universitätsklinik, Homburg/Saar, Federal Republic of Germany

    F. Loew

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag

About this paper

Cite this paper

Bullock, R., Kuroda, Y., Teasdale, G.M., Mcculloch, J. (1992). Prevention of Post-Traumatic Excitotoxic Brain Damage with NMDA Antagonist Drugs: A New Strategy for the Nineties. In: da Silva, A.M., Melo, A.R., Loew, F. (eds) Neurotraumatology: Progress and Perspectives. Acta Neurochirurgica, vol 55. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9233-7_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9233-7_15

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9235-1

  • Online ISBN: 978-3-7091-9233-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation