Airway Hyperresponsiveness and Asthma
Measurements of airway responsiveness have improved our understanding of asthma considerably. But of course we still have a lot to learn. In this presentation, am going to start by saying a little about measurement before going on to talk about the interrelationships between hyperresponsiveness and the other characteristics of asthma. The objective of the presentation is to illustrate how these studies have improved our understanding of the nature of asthma and its treatment.
KeywordsAirway Inflammation Airway Hyperresponsiveness Airway Responsiveness Occupational Asthma Bronchial Hyperresponsiveness
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- 4.Hargreave FE, Woolcock AJ, eds:. Airway responsiveness: measurement and interpretation. Mississauga: Astra Pharmaceuticals Canada Ltd, 1985Google Scholar
- 5.Juniper EF, Cockroft DW, Hargreave FE: Histamine and methacholine inhalation tests: Tidal breathing method laboratory procedure and standardisation. Canadian Thoracic Society AB Draco, Lund Sweden, 1991Google Scholar
- 6.Djukanovic R, Roche WR, Wilson JW, Beasley CRW, Twentyman OP, Howarth PH, Holgate ST: Mucosal inflammation in asthma. Am Rev Respir Dis (1990) 142: 134–157Google Scholar
- 7.Gibson PG, Girgis-Gabardo A, Morris MM, Mattoli S, Kay JM, Dolovich J, Denburg J, Hargreave FE: Cellular characteristics of sputum from patients with asthma and chronic bronchitis. Thorax (1989)Google Scholar
- 8.Pin I, Gibson PG, Kolendowicz R, Dolovich J, Denburg J, Hargreave FE: Induced sputum cell characteristics in normal (N) and asthmatic (A) subjects. Eur Respir J (1990) 3 (10): 255SGoogle Scholar
- 9.Gibson PG, Dolovich J Girgis-Gabardo A, Moris MM, Anderson M, Hargreave FE, Denburg JA: The inflammatory response in asthma exacerbation: changes in circulating eosinophils, basophils and their progenitors. Clin Exp Allergy (1990) 20: 661–668Google Scholar
- 11.Gibson PG, Manning PJ, O’Byrne PM, Girgis-Gabardo A, Dolovich J, Denburg JA, Hargreave FE: Allergen-induced asthmatic responses: relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils and their progenitors. Am Rev Respir Dis (1991) 143: 331–335PubMedGoogle Scholar
- 21.Gibson PG, Mattoli S, Sears MR, Dolovich J, Hargreave FE: Variable airflow obstruction in asymptomatic children with methacholine airway hyperresponsiveness. Clin Invest Med (1988) 11 (4): C105Google Scholar
- 24.Gibson PG, Dolovich J, Denburg J, Ramsdale EH, Hargreave FE: Chronic cough: eosinophilic bronchitis without asthma. Lancet (1989) i:1346–1348Google Scholar