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The catecholaminergic innervation of primate prefrontal cortex

  • Conference paper
Book cover Advances in Neuroscience and Schizophrenia

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 36))

Summary

This paper reviews recent studies indicating that the marked expansion and differentiation of the prefrontal cortex in primates is associated with an increase in the complexity of both the regional density and laminar distribution of catecholaminergic afferents. The innervation patterns of these systems in monkey prefrontal cortex appear to accurately predict those in human prefrontal cortex, suggesting that studies in nonhuman primates may be reasonably used to generate hypotheses about the nature of involvement of these systems in disorders such as schizophrenia. In addition, the distinctive developmental pattern of the dopaminergic innervation of primate prefrontal cortex and the possibility of an intrinsic catecholaminergic innervation of primate prefrontal cortex may reveal new avenues of investigation into the roles of prefrontal catecholamines in both normal and pathological states.

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Author information

Authors and Affiliations

  1. Departments of Psychiatry and Behavioral Neuroscience, University of Pittsburgh, 3811 O’Hara Street, Pittsburgh, PA, 15213, USA

    Dr. D. A. Lewis

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  1. Dr. D. A. Lewis
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Editor information

Editors and Affiliations

  1. Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    A. H. Tuma  & S. Gershon  & 

  2. Department of Behavioral Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA

    E. M. Stricker

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© 1992 Springer-Verlag

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Lewis, D.A. (1992). The catecholaminergic innervation of primate prefrontal cortex. In: Tuma, A.H., Stricker, E.M., Gershon, S. (eds) Advances in Neuroscience and Schizophrenia. Journal of Neural Transmission, vol 36. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9211-5_9

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  • DOI: https://doi.org/10.1007/978-3-7091-9211-5_9

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82347-7

  • Online ISBN: 978-3-7091-9211-5

  • eBook Packages: Springer Book Archive

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