The catecholaminergic innervation of primate prefrontal cortex
This paper reviews recent studies indicating that the marked expansion and differentiation of the prefrontal cortex in primates is associated with an increase in the complexity of both the regional density and laminar distribution of catecholaminergic afferents. The innervation patterns of these systems in monkey prefrontal cortex appear to accurately predict those in human prefrontal cortex, suggesting that studies in nonhuman primates may be reasonably used to generate hypotheses about the nature of involvement of these systems in disorders such as schizophrenia. In addition, the distinctive developmental pattern of the dopaminergic innervation of primate prefrontal cortex and the possibility of an intrinsic catecholaminergic innervation of primate prefrontal cortex may reveal new avenues of investigation into the roles of prefrontal catecholamines in both normal and pathological states.
KeywordsPrefrontal Cortex Tyrosine Hydroxylase Dopaminergic Innervation Human Neocortex Laminar Pattern
Unable to display preview. Download preview PDF.
- Cazzullo CL, Vita A, Sacchetti E (1989) Cerebral vertricular enlargement in schizophrenia: prevalence and correlates. In: Schultz SC, Tamminga CA (eds) Schizophrenia: scientific progress. Oxford University Press, New York, pp 195–206Google Scholar
- Fuster JM (1989) The prefrontal cortex: anatomy, physiology and neuropsychology of the frontal lobe, 2nd edn. Raven Press, New YorkGoogle Scholar
- Goldman-Rakic PS (1987a) Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In: Plum F, Montcastle V (eds) Handbook of physiology — the nervous system, vol 5. American Physiological Society, Bethesda MD, pp 373–417Google Scholar
- Morrison JH, Hof PR, Janssen W, Bassett JL, Foote SL, Kraemer JW, McKinney WT (1990) Quantitative neuroanatomic analyses of cerebral cortex in rhesus monkeys from different rearing conditions. Soc Neurosci Abstr 16: 789Google Scholar
- Weinberger DR, Berman KF, Zec RF (1986) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow (rCBF) evidence. Arch Gen Psychiatry 43: 114–125Google Scholar
- Wyatt RJ (1985) The dopamine hypothesis: variations on a theme. In: Cancro R, Dean SR (eds) Research in the schizophrenic disorders. Spectrum Publications (The Stanley R. Dean Award Lectures, vol 2 ), pp 225–247Google Scholar