The dorsolateral prefrontal cortex, schizophrenia and PET
Central neurophysiology can be measured with PET. These measurements are providing insights into the regional abnormalities associated with schizophrenia. Cohorts of schizophrenic subjects have been studied cross-sectionally in attempts to identify common regional deficits. More recently the advent of fast dynamic measurements of regional cerebral blood flow have allowed rapid serial measurements in the same subject in different brain states (activation studies). These complementary approaches are based upon, and are interpreted with reference to, a number of methodological considerations and underlying hypotheses. The key hypotheses underpining cross-sectional and activation studies are discussed within the framework of the lesion model and functional anatomy models of brain function. This brief review of some assumptions, ideas and methodological constraints is illustrated with empirical data implicating the dorsolateral prefrontal cortex in schizophrenic symptoms.
KeywordsPositron Emission Tomography Verbal Fluency Dorsolateral Prefrontal Cortex Statistical Parametric Mapping Regional Cerebral Blood Flow
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- American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn. American Psychiatric Press, Washington DCGoogle Scholar
- Andreasen NC (1986) Comprehensive assessment of symptoms and history. College of Medicine, University College of Iowa, IowaGoogle Scholar
- Arndt S, Alliger RJ,. Andreasen NC (1991) The distinction of positive and negative symptoms: the failure of a two-dimensional model. Br J Psychiatry 158: 317–322Google Scholar
- Friston KJ, Grasby PJ, Bench CD, Frith CD, Dolan RD, Cowen PJ, Liddle PF, Frackowiak RSJ (1991d) The neurotransmitter basis of cognition: psychopharmacological activation studies using PET. In: Exploring functional anatomy with positron emission tomography. Wiley, Chichester (CIBA Foundation Symposium 163) (in press)Google Scholar
- Goldman-Rakic PS (1986) Circuitry of primate prefrontal cortex and regulation of behaviour by representational memory. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Handbook of physiology, V. American Physiological Society, Philadelphia, pp 373–417Google Scholar
- Goltz F (1881) In: MacCormac WJW (ed) Transactions of the 7th International Medical Congress, vol 1. Kolkmann, London, pp 218–228Google Scholar
- Liddle PF, Friston KJ, Frith CD, Hirsch SR, Frackowiak RSJ (1991) Cerebral blood flow abnormalities associated with schizophrenic syndromes. Biol Psychiatry 29: 716S - 717SGoogle Scholar
- Passingham RE, Chen YC, Thaler D (1989) Supplementary motor cortex and self initiated movement. In: Ito M (ed) Neural programming. Japan Scientific Societies Press, Tokyo, pp 13–24Google Scholar
- Phillips CG, Zeki S, Barlow HB (1984) Localization of function in the cerebral cortex. Past, present and future. Brain 107: 327–361Google Scholar
- Talaraich J, Tournoux P (1988) A co-planar stereotaxic atlas of a human brain. Thieme, StuttgartGoogle Scholar
- Wise S (1989) Frontal cortex activity and motor set. In: Ito M (ed) Neural programming. Japan Scientific Societies Press, Tokyo, pp 25–38Google Scholar