On the influence of spatial resolution and of the size and form of regions of interest on the measurement of regional cerebral metabolic rates by positron emission tomography

  • T. Kuwert
  • T. Sures
  • H. Herzog
  • M. Loken
  • M. Hennerici
  • K.-J. Langen
  • L. E. Feinendegen
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 37)


Factors that affect the accuracy of the positron emission tomographic (PET) quantification of cerebral metabolic rates include the spatial resolution of the employed imaging device and the method used for extraction of regional metabolic values from the PET data set. The present article reviews (i) how and to what extent these two factors are presumed to influence the measurement of absolute values of cerebral metabolic rates and their ratios, and (ii) whether and how these factors may affect comparisons of regional metabolic rates between groups of subjects.


Positron Emission Tomography Partial Volume Effect Cereb Blood Flow Positron Emission Tomography Cerebral Metabolic Rate 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. Kuwert
    • 1
  • T. Sures
    • 1
  • H. Herzog
    • 1
  • M. Loken
    • 1
    • 2
  • M. Hennerici
    • 3
  • K.-J. Langen
    • 1
  • L. E. Feinendegen
    • 1
  1. 1.Institute of MedicineResearch Center JülichJülichFederal Republic of Germany
  2. 2.Division of Nuclear MedicineUniversity of Minnesota Medical CenterMinneapoliUSA
  3. 3.Department of NeurologyUniversity of HeidelbergKlinikum MannheimFederal Republic of Germany

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