Pharmacological models of generalized absence seizures in rodents

  • O. Carter SneadIII
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 35)


A number of animal models of generalized absence seizures in rodents are described. These include absence seizures induced by γ-hydroxybutyrate (GHB), low dose pentylenetetrazole, penicillin, THIP and AY-9944. All of these models share behavioral and EEG similarity to human absence seizures and show pharmacologic specificity for antiabsence drugs such as ethosuximide and trimethadione. Moreover, the absence seizures induced by these agents are exacerbated by GABAergic agonists, a property unique to experimental absence seizures. These models are predictable, reproducible, and easy to standardize. They are useful both in studying mechanisms of pathogenesis of absence seizures as well as in screening for antiabsence activity of potential antiepileptic drugs.


Absence Seizure Wave Discharge Gaba Agonist Potential Antiepileptic Drug GABAergic Agonist 
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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • O. Carter SneadIII
    • 1
    • 2
  1. 1.Division of Neurology, Children’s Hospital, Los Angeles, and Department of NeurologyUniversity of Southern California School of MedicineLos AngelesUSA
  2. 2.Division of NeurologyChildren’s Hospital, Los AngelesLos AngelesUSA

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