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GABA receptors in rats with spontaneous generalized nonconvulsive epilepsy

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Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 35))

Summary

We have used the technique of autoradiography to study the binding of [3H]-GABA to GABAA and GABAB receptors in brains taken from rats that are genetically predisposed to petit mal type seizures. A range of concentrations of [3H]-GABA were employed to test the hypoth­esis that this predisposition was due to regional changes in either the number of GABAA or GABAB receptors, or affinity of GABA for these receptors.

We found no statistical difference in the levels of radioligand binding to GABAA and GABAB receptors in animals susceptible to seizures compared to control animals in any of the brain regions studied over the concentration range 25 nM to 400 nM. This indicated that there was no change in either the Kd (affinity) or Bmax (receptor number) in these animals and that the pharmacological basis for the efficacy of GABAB antagonists in this seizure condition probably lies elsewhere.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, School of Pharmacy, London, UK

    A. R. Knight & Prof. N. G. Bowery

  2. Department of Pharmacology, School of Pharmacy, 29-39 Brunswick Square, London, WC1N lAX, UK

    Prof. N. G. Bowery

Authors
  1. A. R. Knight
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  2. Prof. N. G. Bowery
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Editor information

Editors and Affiliations

  1. Clinique Neurologique, Hôpital Civil, Strasbourg, France

    C. Marescaux

  2. Centre de Neurochimie, C.N.R.S., Strasbourg, France

    M. Vergnes

  3. Pharma Division, Ciba-Geigy AG, Basel, Switzerland

    R. Bernasconi

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© 1992 Springer-Verlag

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Knight, A.R., Bowery, N.G. (1992). GABA receptors in rats with spontaneous generalized nonconvulsive epilepsy. In: Marescaux, C., Vergnes, M., Bernasconi, R. (eds) Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors. Journal of Neural Transmission, vol 35. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9206-1_13

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  • DOI: https://doi.org/10.1007/978-3-7091-9206-1_13

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82340-8

  • Online ISBN: 978-3-7091-9206-1

  • eBook Packages: Springer Book Archive

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