Zusammenfassung
Auswirkungen des Multiorganversagens auf humorale Hämostasefaktoren stehen derzeit nicht im Mittelpunkt der pathobiochemischen Forschung. Dagegen werden die verschiedenen Botenstoffe von Entzündungs- und Abwehrzellen (Tumor-Nekrose-Faktor, Interleukine), die Regulation der Expression der verschiedenen Entzündungsmediatoren, sowie die beteiligten Signaltransduktionsmechanismen auf zellulärer Ebene intensiv untersucht. Methodische Weiterentwicklungen haben jetzt einen tieferen Einblick in die Funktionen von Endothelzellen, Leukozyten und Thrombozyten bei der Entzündungsreaktion zugelassen. Dabei zeigte sich ein umfangreiches zell- bzw. membranständiges Potential an Hämostase-spezifischen Rezeptoren, Kofaktoren und Aktivatoren.
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Spannagl, M. (1992). Multiorganversagen — DIC — welche Fragen sind offen?. In: Deutsch, E., et al. Multiorganversagen. Intensivmedizinisches Seminar, vol 4. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9201-6_9
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DOI: https://doi.org/10.1007/978-3-7091-9201-6_9
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