Zusammenfassung
Bis in die siebziger Jahre verstarb die Mehrzahl der Intensivpatienten an ihrem Grundleiden, im Schock, in der Sepsis oder aufgrund eines gravierenden Organversagens (z. B. akute Niereninsuffizienz, akute respiratorische Insuffizienz). Aufgrund der dramatischen Verbesserungen der Intensivmedizin in den achtziger Jahren verlor das primäre Organversagen seine Schrecken. Heute zählen Hämodialyse und -filtration, Modifikation der Beatmung (z. B. PEEP, inversed ratio Beatmung, high frequency Beatmung, seitendifferente Beatmung, permissive Hyperkapnie), spezifische Gerinnungstherapie, potentere Antibiotika, Immuntherapie, Streßblutungsprophylaxe, adäquate Sedierung bzw. Analgesie und nicht zuletzt die verbesserten Möglichkeiten des invasiven Monitorings mit Optimierung der Volumen- und Katecholamintherapie zu den Bausteinen der modernen Intensivtherapie. Trotzdem versterben auch unter Einsatz dieser und weiterer Maßnahmen noch zu viele Patienten auf der Intensivstation. Geändert haben sich jedoch die Todesursachen. Neben der Grunderkrankung steht heute vor allem das multiple Organversagen an vorderer Stelle der Mortalitätsstatistiken auf Intensivstationen.
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Literatur
Alexander J, MacMillan BG, Stinnet JD, Ogle G, Bozian R, Fischer JE, Oakes J, Morris M, Krummnel R (1980) Beneficial effects of aggressive protein feeding in severely burned children. Ann Surg 192: 505–518
Alverdi JC, Aoys E, Moss GS (1988) Total parenteral nutrition promotes bacterial translocation from the gut. Surgery 104: 185–190
Baker S, O’ Neill B, Haddon W (1974) The injury severity score. A method for describing patients with multible injuries. J Trauma 14: 187–196
Beutler B, Cerami A (1988) Tumor necrosis, cachexia, shock, and inflammation. A common mediator. Annu Rev Bichem 57: 505–518
Blair PH, Webb CH, Lowry K, et al (1991) Use of selective decontamination of the digestive tract (SDD) in an intensive care unit (ICU), an open prospective randomized concurrent controlled trial. ICC, Berlin, 23.-28. 6. 1991
Bone L, Johnson K, Weigelt J, Scheinberg R (1989) Early versus delayed stabilization of femoral fracture stabilization: a prospective randomized study. J Bone Joint Surg 71: 336–340
Border J, Hassett J, LaDuca J, Seibel R, Steinberg S, Mills B, Losi P, Border D (1987) The gut origin septic states in blunt multiple trauma (ISS = 40) in the I.C.U. Ann Surg 206: 427–448
Burke J, Quinby W, Bondoc C (1976) Primary excision and prompt grafting as routine therapy fpr the treatment of thermal burns in children. Surg Clin North Am 56: 477–494
Burke D, Alverdy JC, Aoys E, Mose G (1989) Glutamine-supplement TPN improves gut immune function. Arch Surg 124: 1396–1399
Byrne C, Sielaff TD, Michna B, Carey PD, Blocher CR, Vasquez A, Sugerman HJ (1990) Increased survival time after delayed histamine and prostaglandin blockade in a porcine model of severe sepsis-induced lung injury. Crit Care Med 18: 303308
Cerra FB, Shronts E, Konstantinides NN, Konstantinides FN, Teasley KM (1985) Enteral feeding in sepsis: a prospective, randomized, double-blind trial. Surgery 98: 632–639
Cerra FB, McPherson JP, Konstantinides FN, Konstantinides NN, Teasley KM (1988) Enteral nutrition does not prevent multiple organ failure syndrome ( MOFS) after sepsis. Surgery 104: 727–733
Coccia MT, Waxman K, Soliman MH, Tominaga G, Pinderski L (1989) Pentoxifylline improves survival following hemorrhagic shock. Crit Care Med 17: 36–38
Cromwell RE, Chick TW, Reed WP (1990) Pentoxifylline relaxes isolated pulmonary arteries after preconstriction with norepinephrine. Respiration 57: 45–50
Daly JM, Liebermann M, Goldfine J, Shou J, Weintraub FN, Rosato EF, Lavin P (1991) Enteral nutrition with supplemental arginine, RNA and omega-3 fatty acids: a prospective clinical trial. J Par Ent Nutr 15 [Suppl]
Deitch EA, Bridges W, Baker J, Ma J W, Ma L, Grisham MB, Granger DN, Specian RD, Berg R (1988) Hemorrhagic shock-induced bacterial translocation ist reduced by xanthine oxidase inhibition or inactivation. Surgery 104: 191–198
Feistauer, SM, Laggner AN, Makristathis A, Georgopoulos A (1991) Influence of stress ulcer prophylaxis on translocation of bacteria from the intestinal tract in rats. 17th Int Congr Chemother, Berlin, June 23–28, 1991 (Abstract)
Flanagan JJ, Rush BF, Murphy TF, Smith S, Machledo GW, Hsieh J, Rosa DM, Heneghan JB (1990) A “treated” model for severe hemorrhagic shock: a comparison of conventional and germ-free animals. J Med 21: 104–120
Garcia-Sabride JL, Tallado JM, Christou NV, Polo JR, Valdecantos E (1988) Treatment of servere intraabdominal sepsis and/or necrotic foci by an “open-abdomen” approach, zipper and zipper-mash techniques. Arch Surg 123: 152–146
Goris RJA, Gimbrere JSF, van Niekerk JLM, Schoots FJ, Booy LHD (1982) Early osteosynthesis and prophylactic mechanical ventilation in the multitrauma patient. J Trauma 22: 895–903
Goris RJA, van Bebber IPT, Mollen RMH, Koopman JP (1991) Does selective decontamination of the gastrointestinal tract prevent multiple organ failure? Arch Surg 126: 561–565
Gottschilch MM, Jenkins M, Warden GD, Baumer T, Havens P, Snook JT, Alexander JW (1990) Differential effects of three enteral dietary regimens on selected outcome variables in burn patients. J Par Ent Nutr 14: 225–236
Grant J (1988) Use of L-glutamine in total parenteral nutrition. J Surg Res 44: 506–513
Jackson RJ, Smith SD, Boyle PA, Rowe MI (1991) Preoperative selective decontamination of the digestive tract and poyethylene glycol eliminates lapratomy induced bacterial translocation. Crit Care Med 19: 594
Johnson K, Cadambi A, Seibert G (1985) Incidence of adult respiratory destress syndrome in patients with multiple musculoskeletal injuries: effect of early operative stabilization of fractures. J Trauma 25: 375–384
Konrad F, Schwalbe B, Heeg K, Wagner H, Wiedeck H, Kilian J, Ahnefeld FW (1989) Kolonisations-, Pneumoniefrequenz and Resistenzentwicklung bei langzeitbeatmeten Intensivpatienten unter selektiver Dekontamination des Verdauungstraktes. Anaesthesist 38: 99–109
Ledingham IM, Eastaway AT, McKay IC, Alcock SR, McDonald JC, Ramsay G (1988) Triple regimen of selective decontamination of the digestive tract, systemic cefotaxime, and microbiological surveillance for prevention of acquired infections in intensive care. Lancet is 785–790
Marzi I, Rose S, Bühren V (1991) Prävention des Multiorganversagens nach Trauma durch Einsatz des Sauerstoffradikalscavengers rh-Superoxid Dismutase. Intensivmed Notfallmed 28: 443
Meek RN, Vivoda EE, Crichton H (1981) A comparison of mortality in patients with multiple injuries according to method of fracture treatment. J Bone Joint Surg 63 (B): 456
Meek RN, Vivoda EE, Pirani S (1986) Comparison of mortality of patients with multipe injuries according to type of fracture treatment — a retrospective age — and injury-matched series. Injury 17: 2–4
Moore FA, Moore EE, Jones TN, McCroskey BL, Peterson VM (1989) TEN versus TPN following major abdominal trauma-reduced septic morbidity. J Trauma 29: 916–923
Reed L, Martin M, Hockman M, Kocka F, Mangiano R, Barrett J (1991) The inhibitory effect of hypertonic saline on bacterial translocation is dependent on the duration of hemorrhagic shock. Crit Care Med 19: 595
Reed L, Martin M, Mangiano R, Newson B, Barrett J (1991) Bacterical translocation following abdominal trauma in humans. Crit Care Med 19: S95
Riska FB, von Bonsdorf H, Hakkinen S, Jaroma H, Kiviluoto O, Paavilanen T (1976) Prevention of fat embolism by early internal fixation of fractures in patients with multiple trauma. Injury 6: 110–116
Riska EB, Nyllynen P (1982) Fat embolism in patients with multiple injuries. J Trauma 22: 891–895
Ruedi T, Wolff G (1975) Vermeidung posttraumatischer Komplikationen durch frühe definitive Versorgung von Polytraumatisierten mit Frakturen des Bewegungsapparates. Heiv Chir Acta 42: 507–512
Rush BF, Sori AJ, Murphy TF (1988) Endotoxemia and bacteremia during hemorrhagic shock. Ann Surg 207: 549–554
Schade U (1990) Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. Circ Shock 31: 171–181
Semmlow J, Cone R (1976) Utility of the injury severity score. Health Service Res 11: 45–52
Singer M, Tighe D, Bennett ED (1990) Pilot study of pentoxifylline in human multi-organ failure. Int Care Med 16 [Suppl 1]: A480
Souba WW, Klimberg VS, Hautamaki RD (1990) Oral glutamine reduces bacterial translocation following abdominal radiation. J Surg Res 48: 1–5
Souba WW, Herskowitz K, Augsten TR, Chen MK, Salloum RM (1990) Glutamine nutrition: theoretical considerations and therapeutic impact. J Par Ent Nutr 14 [Suppl]: 237S - 243S
Teichmann W, Wittmann DH, Andreone PA (1986) Scheduled reoperations ( Etappenlavage) for diffuse peritonitis. Arch Surg 121: 147–152
Tryba M (1989) Side effects of stress bleeding prophylaxis. Am J Med 86 (6A): 85–94
Tryba M (1991) Sucralfate vs antacids or H2-antagonists for stress ulcer prophylaxis — a metaanalysis on the efficacy and pneumonia rate. Crit Care Med 19: 942
Vijaykumar E, Raziuddin S, Wardle EN (1991) Plasma endotoxin in patients with trauma, sepsis and severe haemorrhage. Clin Intens Care 2: 4–9
Walsh GL, Chiasson P, Hedderich G, Wexler MJ, Meakins JL (1988) The open abdomen. The Marlex mesh zipper technique: a method of managing intraperitoneal infection. Surg Clin North Am 68: 25–40
Waxman K, Clark L, Soliman MH, Parazin S (1991) Pentoxifylline in resuscitation of experimental hemorrhagic shock. Crit Care Med 19: 728–731
Zaloga GP, Knewles R, Black KW, Prielipp R (1991) Total parenteral nutrition increases mortality after hemorrhage. Crit Care Med 19: 54–59
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Tryba, M., Brand, J. (1992). Prävention des Multiorganversagens?. In: Deutsch, E., et al. Multiorganversagen. Intensivmedizinisches Seminar, vol 4. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9201-6_19
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