Clinical aspects on presynaptic noradrenaline metabolism

  • J. Ludwig
  • T. Halbrügge
  • K.-H. Graefe
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


In healthy subjects, similar absolute increments in plasma noradrenaline (NA) and dihydroxyphenylglycol (DOPEG) were observed in response to upright posture or isoprenaline infusion. Blockade of neuronal uptake by desipramine abolished these plasma DOPEG responses and reduced plasma DOPEG per se. In essential hypertensives we found higher than normal plasma DOPEG levels at any given plasma NA. Evidence is provided that both the desipramine-sensitive and -resistant pool of plasma DOPEG contribute to this hypertensive-normotensive difference.


Essential Hypertension Upright Posture Quiet Standing Spontaneous Hypertension Neuronal Uptake 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • J. Ludwig
    • 1
  • T. Halbrügge
    • 2
  • K.-H. Graefe
    • 2
  1. 1.Medical SchoolUniversity of WürzburgWürzburgFederal Republic of Germany
  2. 2.Department of PharmacologyUniversity of WürzburgWürzburgFederal Republic of Germany

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