Clinical aspects on presynaptic noradrenaline metabolism
In healthy subjects, similar absolute increments in plasma noradrenaline (NA) and dihydroxyphenylglycol (DOPEG) were observed in response to upright posture or isoprenaline infusion. Blockade of neuronal uptake by desipramine abolished these plasma DOPEG responses and reduced plasma DOPEG per se. In essential hypertensives we found higher than normal plasma DOPEG levels at any given plasma NA. Evidence is provided that both the desipramine-sensitive and -resistant pool of plasma DOPEG contribute to this hypertensive-normotensive difference.
KeywordsEssential Hypertension Upright Posture Quiet Standing Spontaneous Hypertension Neuronal Uptake
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- Izzo JL, Thompson DA, Horwitz D (1985) Plasma dihydroxyphenylglycol ( DHPG) in the in vivo assessment of human neuronal norepinephrine metabolism. Life Sci 58: 1033–1038Google Scholar
- Ludwig J, Gerhardt T, Halbrugge T, Walter J, Heidbreder E, Graefe K-H (1990) Effects of nisoldipine on stress-induced changes in haemodynamics and plasma catecholamines in normotensives and hypertensives. J Human Hypertens 4: 693–701Google Scholar
- Szabo B, Schultheiss A (1990) Desipramine inhibits sympathetic nerve activity in the rabbit. Naunyn-Schmiedebergs Arch Pharmacol 342: 469–476Google Scholar
- Trendelenburg U, Bonisch H, Graefe K-H, Henseling M (1980) The rate constants for the efflux of metabolites of catecholamines and phenethylamines. Pharmacol Rev 31: 179–203Google Scholar