Advertisement

Distribution of extraneuronal uptake1 in reproductive tissues: studies on cells in culture

  • I. S. de la Lande
  • V. Marino
  • T. Lavranos
  • J. A. Kennedy
  • D. A. S. Parker
  • R. F. Seamark
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)

Summary

Cultures of stromal cells from pregnant mouse uterus, and an FL cell line derived from human amnion, displayed significant capacities to O- methylate noradrenaline. O-methylation was inhibited in the stromal cells by uptake1-inhibitors, and in the FL cell line by uptake2 inhibitors. These findings are discussed in terms of the distribution and possible functional importance of catecholamine metabolising systems in the female reproductive system.

Keywords

Dental Pulp COMT Inhibitor Extraneuronal Uptake Hydrocortisone Hemisuccinate Desipramine Hydrochloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. de la Lande IS, Parker DAS, Procter C, Marino V (1987) Cocaine inhibits extraneuronal O-methylation of exogenous noradrenaline in nasal and oral tissues of the rabbit. Life Sci 41: 2463–2468PubMedCrossRefGoogle Scholar
  2. de la Lande Is, Parker DAS, Marino V (1989) O-methylation of noradrenaline is linked with an uptake process which resembles uptake! in dental pulp. J Neurochem 52 [Suppl]: 16Google Scholar
  3. de la Lande IS, Marino V, Kennedy JA, Parker DAS (1990) Further evidence that the extraneuronal uptake of noradrenaline in rabbit dental pulp is similar to uptake i. Eur J Pharmacol 183: 1147–1148CrossRefGoogle Scholar
  4. Garfield RE (1986) Structural studies on innervation of non pregnant rat uterus. Am J Physiol 251: C41–54Google Scholar
  5. Graefe K-H, Stefano FJE, Langer SZ (1973) Prefential metabolism of (-)-3H- noradrenaline through the deaminated glycol in the rat vas deferens. Biochem Pharmacol 22: 1147–1160CrossRefGoogle Scholar
  6. Kennedy JA (1991) Effect of catechol oestrogens on extraneuronal metabolism of noradrenaline by rabbit uterine endometrium and myometrium. Naunyn- Schmiedebergs Arch Pharmacol 343: 266–270PubMedGoogle Scholar
  7. Kennedy JA, de la Lande IS (1986) Effect of progesterone on the metabolism of noradrenaline in the rabbit uterine endometrium and myometrium. Naunyn- Schmiedebergs Arch Pharmacol 333: 368–376Google Scholar
  8. Kennedy JA, de la Lande (1987) Characteristics of cocaine-sensitive accumulation and O-methylation of noradrenaline by rabbit endometrium. Naunyn-Schmiedebergs Arch Pharmacol 336: 148–154Google Scholar
  9. Kennedy JA, de la Lande IS (1988) Catecholamine inactivation in uterine tissues; changes in pregnancy in the rat. Clin Exp Physiol Pharmacol 15: 675–680Google Scholar
  10. Lavranos TC, Seamark RF (1989) Addition of steroids to embryo-uterine monolayer co-culture enhances embryo survival and implantation in vitro. Reprod Fertil Dev 1: 41–46PubMedCrossRefGoogle Scholar
  11. Mondschein JS, Hersey RM, Dey SK, Davis D, Weisz J (1985) Catechol estrogen formation by pig blastocysts: biochemical characterization of estrogen-2/4- hydroxylase and correlation with aromatase activity during the preimplantation period. Endocrinology 117: 2339–2346PubMedCrossRefGoogle Scholar
  12. Nicholas TE, Strum JM, Angelo IS, Junod AF (1974) Site and mechanism of uptake of 3H-l-noradrenaline by isolated perfused rat lungs. Circ Res 35: 670–680PubMedGoogle Scholar
  13. Parker DAS, de la Lande IS, Proctor C, Marino V, Lam NX, Parker I (1987) Cocaine-sensitive O-methylation of noradrenaline in dental pulp; comparison with the rabbit ear artery. Naunyn-Schmiedebergs Arch Pharmacol 336: 32–39Google Scholar
  14. Robertson SA, Searmark RF (1990) Granulocyte macrophage colony stimulating factor ( GM-CSF) in the murine reproductive tract; stimulation by seminal factors. Reprod Fertil Dev 2: 359–368Google Scholar
  15. Schömig E, Schönfeld C-L (1990) Extraneuronal noradrenaline transport (uptake2) in a human cell line. Naunyn-Schmiedebergs Arch Pharmacol 341: 404–410PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • I. S. de la Lande
    • 1
  • V. Marino
    • 2
  • T. Lavranos
    • 3
  • J. A. Kennedy
  • D. A. S. Parker
    • 2
  • R. F. Seamark
    • 3
  1. 1.Department of Clinical and Experimental PharmacologyUniversity of AdelaideAdelaideAustralia
  2. 2.Department of DentistryUniversity of AdelaideAdelaideAustralia
  3. 3.Department of Obstetrics and GynaecologyUniversity of AdelaideAdelaideAustralia

Personalised recommendations