Energy requirements for the basal efflux of noradrenaline and its metabolites from adrenergic varicosities

  • U. Trendelenburg
  • H. Russ
  • E. Schömig
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


The combination of hypoxia plus glucose deprivation or of hypoxia plus lactate induces carrier-mediated outward transport of 3H-noradrenaline in the rat vas deferens. Lactate efflux is higher from atria than from vas deferens. Hence, the much lower contribution by outward transport to the spontaneous efflux of 3H-noradrenaline in vas deferens than atria is likely to be due to a better supply of oxygen (and perhaps also glucose) to the 3H-noradrenaline- storing varicosities in vas deferens than in atria.


Glucose Deprivation Iodo Acetic Acid Lactate Formation Outward Transport Basal Efflux 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Apps DK, Pryde JG, Sutton R, Phillips JH (1980) Inhibition of adenosine triphosphatase, 5 hydroxytryptamine transport and proton translocation activities of resealed chromaffin-granule “ghosts”. Biochem J 190: 273–282PubMedGoogle Scholar
  2. Azevedo I, Moura D, Trendelenburg U (1990) Autoradiographic study of the rat vas deferens incubated with 3H-noradrenaline. Naunyn-Schmiedebergs Arch Pharmacol 342: 245–248PubMedCrossRefGoogle Scholar
  3. Hamberger B (1967) Reserpine-resistant uptake of catecholamines in isolated tissues of the rat. Acta Physiol Scand 71 [Suppl 295]: 1–56CrossRefGoogle Scholar
  4. Hermann W, Graefe K-H (1977) Relationship between the uptake of 3H-metaraminol and the density of adrenergic innervation in isolated rat tissues. Naunyn- Schmiedebergs Arch Pharmacol 296: 99–110PubMedCrossRefGoogle Scholar
  5. Paton DM (1968) Cation and metabolic requirements for retention of metaraminol by rat uterine horn. Br J Pharmacol 33: 277–286Google Scholar
  6. Paton DM (1972) Metabolic requirements for the uptake of noradrenaline by isolated atria and vas deferens of the rabbit. Pharmacology 7: 78–88PubMedCrossRefGoogle Scholar
  7. Paton DM (1973) Mechanism of efflux of noradrenaline from adrenergic nerves in rabbit atria. Br J Pharmacol 49: 614–627PubMedGoogle Scholar
  8. Russ H, Schomig E, Trendelenburg U (1991) The energy requirements for the efflux of noradrenaline from adrenergic varicosities. Naunyn-Schmiedebergs Arch Pharmacol 344: 286–296PubMedGoogle Scholar
  9. Schömig E, Trendelenburg U (1987) Simulation of outward transport of neuronal 3H- noradrenaline with the help of a two-compartment model. Naunyn-Schmiedebergs 4 Arch Pharmacol 336: 631–640CrossRefGoogle Scholar
  10. Schömig A, Fischer S, Kurz T, Richardt G, Schomig E (1987) Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic rat heart: mechanism and metabolic requirements. Circ Res 60: 194–205PubMedGoogle Scholar
  11. Schömig E, Fischer P, Schonfeld C-L, Trendelenburg U (1989) The extent of neuronal re-uptake of 3H-noradrenaline in isolated vasa deferentia and atria of the rat. Naunyn-Schmiedebergs Arch Pharmacol 340: 502–508PubMedGoogle Scholar
  12. Schömig E, Schonfeld C-L, Halbrugge T, Graefe K-H, Trendelenburg U (1990) The heterogeneity of the neuronal distribution of exogenous noradrenaline in the rat vas deferens. Naunyn-Schmiedebergs Arch Pharmacol 342: 160–170PubMedCrossRefGoogle Scholar
  13. Schömig E, Trendelenburg U, Azevedo I, Moura D (1991) The steady-state concentration gradient for 3H-noradrenaline generated by uptake! in the extracellular space of the rat vas deferens incubated with this amine. Naunyn- Schmiedebergs Arch Pharmacol 344: 41–46PubMedGoogle Scholar
  14. Stute N, Trendelenburg U (1984) The outward transport of axoplasmic noradrenaline induced by a rise of the sodium concentration in the adrenergic nerve endings of the rat vas deferens. Naunyn Schmiedebergs Arch Pharmacol 327: 124–132PubMedCrossRefGoogle Scholar
  15. Sweadner KJ (1985) Ouabain-evoked norepinephrine release from intact rat sympathetic neurons: evidence for carrier-mediated release. J Neurosci 5: 2397–2406PubMedGoogle Scholar
  16. Wakade AR, Furchgott RF (1968) Metabolic requirements for the uptake and storage of norepinephrine by the isolated left atrium of the guinea pig. J Pharmacol Exp Ther 163: 123–135PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • U. Trendelenburg
    • 1
  • H. Russ
    • 1
  • E. Schömig
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of WürzburgWürzburgFederal Republic of Germany

Personalised recommendations