Energy requirements for the basal efflux of noradrenaline and its metabolites from adrenergic varicosities
The combination of hypoxia plus glucose deprivation or of hypoxia plus lactate induces carrier-mediated outward transport of 3H-noradrenaline in the rat vas deferens. Lactate efflux is higher from atria than from vas deferens. Hence, the much lower contribution by outward transport to the spontaneous efflux of 3H-noradrenaline in vas deferens than atria is likely to be due to a better supply of oxygen (and perhaps also glucose) to the 3H-noradrenaline- storing varicosities in vas deferens than in atria.
KeywordsGlucose Deprivation Iodo Acetic Acid Lactate Formation Outward Transport Basal Efflux
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