Cyclic AMP and adaptive supersensitivity in guinea pig atria

  • W. W. Fleming
  • D. A. Taylor
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


Supersensitivity was induced by injection of guinea pigs with reserpine, 0.1mg/kg/day for 7 days. This treatment induced chronotropic supersensitivity of isolated right atria to isoproterenol but not to forskolin. The pretreatment induced supersensitivity to the cyclic AMP-generating effects of isoproterenol or forskolin in left, but not right, atria. These results are dis-cussed in reference to the extensive literature describing supersensitivity in the guinea-pig heart, including the possible role of the adenylyl cyclase system.


Left Atrium Adenylyl Cyclase Adenylyl Cyclase System Grass Polygraph Reserpine Pretreatment 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • W. W. Fleming
    • 1
  • D. A. Taylor
    • 1
  1. 1.Department of Pharmacology and ToxicologyWest Virginia University Health Sciences CenterMorgantownUSA

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