Mediation by adenosine of the trophic effects exerted by the sympathetic innervation of blood vessels

  • W. Osswald
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


Chemical or surgical sympathetic denervation of blood vessels causes marked changes of the effector cells. Since postganglionic sympathetic cotransmission by noradrenaline and adenosine 5′-triphosphate is well established, the role of these transmitters as putative trophic factors was investigated. Whereas noradrenaline was ineffective in preventing morphological changes due to denervation, both adenosine and N-ethylcarboxamido-adenosine totally prevented them. In conscious rats, the adenosine receptor antagonist dipropylsulphophenylxantine(DPSPX) caused alterations of the blood vessel wall similar to those described for denervation. These results strongly suggest that adenosine is the trophic factor of sympathetic innervation.


Saphenous Vein Sympathetic Innervation Trophic Effect Sympathetic Denervation Noradrenaline Content 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • W. Osswald
    • 1
  1. 1.Department of Pharmacology and Therapeutics, Faculty of MedicinePorto UniversityPortoPortugal

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