Adenosine receptors in the central nervous system

  • U. Schwabe
  • A. Lorenzen
  • S. Grün
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


Two major subclasses of adenosine receptors have been distinguished in the central nervous system, termed A1 and A2. They are coupled to G-proteins and regulate the activity of adenylyl cyclase, potassium channels and several other effector systems. Autoradiographic studies have shown that Ax receptors are mainly found in the hippocampus and the cerebellum, whereas A2 receptors are almost exclusively located in the striatum and olfactory tubercle. Furthermore, a novel adenosine binding protein was identified in bovine striatum by radioligand binding with [3H]5′-N-ethylcarboxamidoadenosine ([3H]NECA). The pharmacological profile of this NECA binding protein has been determined in competition experiments with adenosine receptor ligands. It can be distinguished from that of A2 adenosine receptors and other adenosine binding proteins such as S-adenosylhomocysteine hydrolase and the adenosine transporter.


Adenylyl Cyclase Adenosine Receptor Adenosine Receptor Agonist Adenosine Transporter Adenosine Receptor Ligand 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • U. Schwabe
    • 1
  • A. Lorenzen
    • 1
  • S. Grün
    • 1
  1. 1.Department of PharmacologyUniversity of HeidelbergHeidelbergFederal Republic of Germany

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