Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their pharmacological characterization

  • M. Göthert
  • K. Fink
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


In rat brain cortex synaptosomes superfused with Mg2+-free solution containing glycine, [3H]noradrenaline (3H-NA) release evoked by NMD A was abolished by omission of glycine or Ca2+ and inhibited by Mg2+, the competitive and noncompetitive NMDA receptor antagonists CGP 37849 and dizocilpine (MK-801), respectively, as well as by ethanol, but was not affected by tetrodotoxin. The 3H-NA release evoked by L-glutamate was also competitively inhibited by CGP 37849. In conclusion, presynaptic NMDA receptors mediate stimulation of NA release. Ethanol probably acts at this receptor system.


NMDA Receptor Noradrenaline Release Kainate Receptor Excitatory Amino Acid Receptor Cortical Synaptosome 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • M. Göthert
    • 1
  • K. Fink
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of BonnBonn 1Federal Republic of Germany

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