Preliminary evidence for noradrenaline and ATP as neurotransmitters in the porcine isolated palmar common digital artery

  • V. G. Wilson
  • N. A. Blaylock
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


Sympathetic neurotransmission in porcine isolated palmar common digital artery involves the release of noradrenaline and ATP which produce constrictor responses via α1-adrenoceptor and P2x receptors, respectively. Responses to short trains of pulses (e.g. 4 pulses at 2Hz) are almost entirely attributable to ATP, while those to longer trains of pulses appear to involve both transmitters. Unlike the corresponding blood vessel in man (Stevens and Mould, 1985) no evidence for “innervated” post-junctional α2-adrenoceptors was found.


Electrical Field Stimulation Sympathetic Nerve Stimulation Short Train Sympathetic Neurotransmission Saphenous Artery 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • V. G. Wilson
    • 1
  • N. A. Blaylock
    • 1
  1. 1.Department of Physiology and Pharmacology, The Medical SchoolQueen’s Medical CentreNottinghamUk

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