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Noradrenaline-ATP corelease and cotransmission following activation of nicotine receptors at postganglionic sympathetic axons

  • K. Starke
  • R. Bültmann
  • J. M. Bulloch
  • I. von Kügelgen
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)

Summary

In rabbit mesenteric arteries, nicotine-evoked vasoconstrictor responses were markedly reduced by prazosin, slightly reduced after desen- sitization by α, β-methylene ATP, and abolished by combined treatment with prazosin and α, β-methylene ATP. In guinea-pig vasa deferentia preincubated with [3H]noradrenaline, nicotine elicited contractions as well as an overflow of tritium and of ATP. The contractions were greatly reduced by prazosin and abolished after additional desensitization by α, β-methylene ATP. The nicotine- induced overflow of tritium was not changed by either treatment. The overflow of ATP was decreased by prazosin but not diminished further after additional desensitization by α, β-methylene ATP. Activation of prejunctional nicotine receptors elicits a corelease of noradrenaline and ATP which leads to eotransmission in both tissues.

Keywords

Sympathetic Nerve Stimulation Ileocolic Artery Sympathetic Axon Exogenous Noradrenaline Postganglionic Sympathetic Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • K. Starke
    • 1
  • R. Bültmann
    • 1
  • J. M. Bulloch
    • 1
  • I. von Kügelgen
    • 1
  1. 1.Institute of PharmacologyFreiburg i.Br.Federal Republic of Germany

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