Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valproate in mice

  • Z. Kleinrok
  • J. Gustaw
  • S. J. Czuczwar
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


The tricyclic antidepressants, amitriptiline (20–30 mg/kg, i.p.) and imipramine (30–40mg/kg), provided a significant protection against electro- convulsions (12 mA, 0.2 s stimulus duration) but desipramine (up to 40 mg/kg) remained ineffective. On the other hand, all drugs, amitriptiline (10mg/kg), desipramine (20mg/kg), and imipramine (20mg/kg) distinctly potentiated the protective efficacy of valproate against maximal electroshock, reducing its ED 50 values from 255 mg/kg to 150, 135, and 128 mg/kg, respectively. In one case the plasma valproate level was measured and it was evident that desipramine (20 mg/kg) did not affect the plasma level of this antiepileptic.


Antidepressant Drug Anticonvulsant Activity Protective Efficacy Seizure Susceptibility Maximal Electroshock Seizure 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Z. Kleinrok
    • 1
  • J. Gustaw
    • 1
  • S. J. Czuczwar
    • 1
  1. 1.Department of PharmacologyMedical SchoolLublinPoland

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