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Effects of imipramine and some tryptamine derivatives on the efflux of 3H-5-hydroxytryptamine from rabbit platelets

  • K.-H. Graefe
  • R. Wölfel
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)

Summary

The efflux of 3H-5-hydroxytryptamine (3H-5-HT) from rabbit platelets (monoamine oxidase inhibited; pretreatment with reserpine) was measured in the absence and presence of various concentrations of imipramine or a number of tryptamine derivatives. The maximum efflux-accelerating effect (Emax) of 5-HT and some other tryptamines (e.g., N-methyl-5-HT, 5- methoxytryptamine) far exceeded that of imipramine, whereas the Emax for 2-methyl-5-HT did not. It is concluded that tryptamines that are more effective in releasing 3H-5-HT than imipramine have the property of being substrates of the 5-HT transporter.

Keywords

Blood Platelet Tritium Content Rabbit Platelet Sympathomimetic Amine Outward Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • K.-H. Graefe
    • 1
  • R. Wölfel
    • 2
  1. 1.Department of Pharmacology and ToxicologyUniversity of WürzburgFederal Republic of Germany
  2. 2.Institute of Pharmacology and ToxicologyUniversity of WürzburgWürzburgFederal Republic of Germany

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