The effects of electroconvulsive shock on catecholamine function in the locus ceruleus and hippocampus
Repeated electroconvulsive shock (ECS) treatment (once per day for 7 days) produced a significant increase in tyrosine hydroxylase activity, GTP-cyclohydrolase activity and tetrahydrobiopterin (BH4) levels in the locus ceruleus and hippocampus from 1 to 4 days after the last treatment. These changes may be responsible for, or contribute to, the antidepressant effect of ECS treatment.
KeywordsTyrosine Hydroxylase Antidepressant Effect Locus Ceruleus Electroconvulsive Shock Tyrosine Hydroxylase Activity
Unable to display preview. Download preview PDF.
- Duch DS, Bowers SW, Woolf JH, Nichol CA (1984) Bioterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species. Life Sci 35: 1895–1901Google Scholar