The effects of electroconvulsive shock on catecholamine function in the locus ceruleus and hippocampus

  • N. Weiner
  • M. A. Hossain
  • J. M. Masserano
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 34)


Repeated electroconvulsive shock (ECS) treatment (once per day for 7 days) produced a significant increase in tyrosine hydroxylase activity, GTP-cyclohydrolase activity and tetrahydrobiopterin (BH4) levels in the locus ceruleus and hippocampus from 1 to 4 days after the last treatment. These changes may be responsible for, or contribute to, the antidepressant effect of ECS treatment.


Tyrosine Hydroxylase Antidepressant Effect Locus Ceruleus Electroconvulsive Shock Tyrosine Hydroxylase Activity 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • N. Weiner
    • 1
  • M. A. Hossain
    • 1
  • J. M. Masserano
    • 1
  1. 1.Department of Pharmacology, C-236University of Colorado Health Sciences CenterDenverUSA

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