Animal Experiments with Interstitial Water Hyperthermia
Invasive hyperthermia methods have been developed as an alternative when noninvasive systems are inefficient or not adapted for producing therapeutic temperatures throughout the entire tumor volume, without overheating normal tissues. Another major interest is the synergistic effect of interstitial hyperthermia combined with irradiation (Emani et al, 1984; Cosset et al, 1985a). When interstitial irradiation is combined with external irradiation or is employed alone, the heating can be added using previously implanted catheters. Thus, the heating could be better localized and controlled than in noninvasive methods. This is particularly true for deep-seated tumors where hyperthermic levels cannot be always obtained by noninvasive methods (Dutreix et al, 1982). The methods for interstitial hyperthermia mostly used at present are implantable microwave antennas, localized current fields, and ferromagnetic seeds (e.g. Strohbehn and Mechling, 1986; Stauffer et al, 1989). The ferromagnetic seed technique differs from the other two in that the heating of tissue is completely dependent upon its thermal conduction and blood flow cooling. Thermal seeds are in this case “hot sources”. Another hot source can be hot water circulating through an array of implanted tubes (Handl-Zeller et al, 1986) which are subsequently loaded with Ir-192 wires.
KeywordsTissue Temperature Heat Water Heating Tube Microwave Antenna Metal Needle
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- Cosset JM, Dutreix J, Gerbaulet A, Damia E (1984a) Combined interstitial hyperthermia and brachytherapy: The Institute Gustave Roussy experience. In: Overgaard J (ed) Hyperthermic Oncology, vol 1. Taylor and Francis, London, pp 587–590Google Scholar
- Cosset JM, Dutreix J, Gerbaulet A, Damia E (1985a) L’association hyperthermie interstitielle-curietherapie: Une technique de ratrapage des recidives en zones precedemment irradiees. In: Institut Gustave Roussy (ed) Actualites Carcinologiques. Masson, Paris, pp 211–218Google Scholar
- Doss JD, McCabe A (1982) A technique for localized heating in tissue: An adjunct to tumor therapy. Medical Instrumentation 10: 16–20Google Scholar
- Dutreix J, Cosset JM, Salama M, Brule JM, Damia E (1982) Experimental studies of various heating procedures for clinical application of localized hyperthermia. In: Biomedical Thermology. Alan R. Liss Inc., New York, pp 585–596Google Scholar
- Emami B, Marks J, Perez C, Nussbaum G, Leybovich L (1984) Treatment of human tumors with interstitial irradiation and hyperthermia. In: Overgaard J (ed) Hyper-thermic Oncology, vol 1. Taylor & Francis, London, pp 583–586Google Scholar
- Hand JW, Trembly BS, Prior MV (in press) Physics of interstitial hyperthermia. Radiofrequency and hot water tube technique. In: Urano M, Douple E (eds) Hyperthermia and Oncology, vol 3: Interstitial Hyperthermia. Zeist VSP UtrechtGoogle Scholar
- Handl-Zeller L, Kärcher KH, Schreier K, Handl O (1986) Optimierung interstitieller Hyperthermie-Systeme. Strahlentherapie 163: 460–463Google Scholar
- Marchosky JA, Moran C, Fearnot N (1988a) A system for volumetric interstitial hyperthermia. Abstracts 36th annual meeting of Radiation Research Society. RRS, Philadelphia, Abstract Ce-8, p 32Google Scholar
- Marchosky JA, Moran C, Fearnot N (1988b) Volumetric interstitial hyperthermia: Phase 1 clinical study. Abstracts 36th Annual Meeting of Radiation Research Society. RRS, Philadelphia, Abstract Ch-7, p 46Google Scholar
- Strohbehn JW, Mechling JA (1986) Interstitial techniques for clinical hyperthermia. In: Hand JW, James RJ (eds) Physical Techniques in Clinical Hyperthermia. Research Studies Press, Letchworth, pp 210–287Google Scholar
- Strohbehn JW, Bowers ED, Walsh JE, Douple EB (1979) An invasion microwave antenna for locally-induced hyperthermia for cancer therapy. J Microwave Power 14: 339–350Google Scholar