Animal Experiments with Interstitial Water Hyperthermia

  • M. Budihna
  • H. Lesnicar
  • L. Handl-Zeller
  • K. Schreier


Invasive hyperthermia methods have been developed as an alternative when noninvasive systems are inefficient or not adapted for producing therapeutic temperatures throughout the entire tumor volume, without overheating normal tissues. Another major interest is the synergistic effect of interstitial hyperthermia combined with irradiation (Emani et al, 1984; Cosset et al, 1985a). When interstitial irradiation is combined with external irradiation or is employed alone, the heating can be added using previously implanted catheters. Thus, the heating could be better localized and controlled than in noninvasive methods. This is particularly true for deep-seated tumors where hyperthermic levels cannot be always obtained by noninvasive methods (Dutreix et al, 1982). The methods for interstitial hyperthermia mostly used at present are implantable microwave antennas, localized current fields, and ferromagnetic seeds (e.g. Strohbehn and Mechling, 1986; Stauffer et al, 1989). The ferromagnetic seed technique differs from the other two in that the heating of tissue is completely dependent upon its thermal conduction and blood flow cooling. Thermal seeds are in this case “hot sources”. Another hot source can be hot water circulating through an array of implanted tubes (Handl-Zeller et al, 1986) which are subsequently loaded with Ir-192 wires.


Tissue Temperature Heat Water Heating Tube Microwave Antenna Metal Needle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Astrahan MA, Norman A (1982) A localized current field hyperthermia system for use with Ir-192 interstitial implants. Medical Phys 9: 419–424CrossRefGoogle Scholar
  2. Brezovich IA, Atkinson WJ (1984) Temperature distributions in tumor models heated by self-regulating nickel-copper alloy thermoseeds. Med Phys 11: 145–152PubMedCrossRefGoogle Scholar
  3. Cosset JM, Dutreix J, Gerbaulet A, Damia E (1984a) Combined interstitial hyperthermia and brachytherapy: The Institute Gustave Roussy experience. In: Overgaard J (ed) Hyperthermic Oncology, vol 1. Taylor and Francis, London, pp 587–590Google Scholar
  4. Cosset JM, Dutreix J, Dufour J, Janoray P, Damia E, Haie C, Clarke D (1984b) Combined interstitial hyperthermia and brachytherapy: Institute Gustave Roussy technique and preliminary results. Int J Radiat Oncol Biol Phys 10: 307–312PubMedCrossRefGoogle Scholar
  5. Cosset JM, Dutreix J, Gerbaulet A, Damia E (1985a) L’association hyperthermie interstitielle-curietherapie: Une technique de ratrapage des recidives en zones precedemment irradiees. In: Institut Gustave Roussy (ed) Actualites Carcinologiques. Masson, Paris, pp 211–218Google Scholar
  6. Cosset JM, Dutreix J, Haie C, Gerbaulet A, Janoray P, Dewar JA (1985b) Interstitial thermoradiotherapy: A technical and clinical study of 29 implantations performed at the Institut Gustave-Roussy. Int J Hyperthermia 1: 3–13PubMedCrossRefGoogle Scholar
  7. Coughlin CT, Douple EB, Strohbehn JW, Eaton WL, Trembly BS, Wong TZ (1983) Interstitial hyperthermia in combination with brachytherapy. Radiology 148: 285–288PubMedGoogle Scholar
  8. Doss JD, McCabe A (1982) A technique for localized heating in tissue: An adjunct to tumor therapy. Medical Instrumentation 10: 16–20Google Scholar
  9. Dutreix J, Cosset JM, Salama M, Brule JM, Damia E (1982) Experimental studies of various heating procedures for clinical application of localized hyperthermia. In: Biomedical Thermology. Alan R. Liss Inc., New York, pp 585–596Google Scholar
  10. Emami B, Marks J, Perez C, Nussbaum G, Leybovich L (1984) Treatment of human tumors with interstitial irradiation and hyperthermia. In: Overgaard J (ed) Hyper-thermic Oncology, vol 1. Taylor & Francis, London, pp 583–586Google Scholar
  11. Field SB, Morris CC (1983) The relationship between heating time and temperature: Its relevance to clinical hyperthermia. Radiother Oncol 1: 179–186PubMedCrossRefGoogle Scholar
  12. Hand JW, Trembly BS, Prior MV (in press) Physics of interstitial hyperthermia. Radiofrequency and hot water tube technique. In: Urano M, Douple E (eds) Hyperthermia and Oncology, vol 3: Interstitial Hyperthermia. Zeist VSP UtrechtGoogle Scholar
  13. Handl-Zeller L, Kärcher KH, Schreier K, Handl O (1986) Optimierung interstitieller Hyperthermie-Systeme. Strahlentherapie 163: 460–463Google Scholar
  14. Kapp DS, Fessenden P, Samulski TV, Bagshaw MA, Cox RS, Lee ER, Lohrbach AW, Meyer JL, Prionas SD (1988) Stanford University institutional report. Phase I evaluation of equipment for hyperthermia treatment of cancer. Int J Hyperthermia 4: 75–115PubMedCrossRefGoogle Scholar
  15. Manning MR, Cetas TC, Miller RC, Oleson JR, Corner WG, Gerner EW (1982) Clinical hyperthermia: Results of a phase I trial employing hyperthermia alone or in combination with external beam or interstitial radiotherapy. Cancer 49: 205–216PubMedCrossRefGoogle Scholar
  16. Marchosky JA, Moran C, Fearnot N (1988a) A system for volumetric interstitial hyperthermia. Abstracts 36th annual meeting of Radiation Research Society. RRS, Philadelphia, Abstract Ce-8, p 32Google Scholar
  17. Marchosky JA, Moran C, Fearnot N (1988b) Volumetric interstitial hyperthermia: Phase 1 clinical study. Abstracts 36th Annual Meeting of Radiation Research Society. RRS, Philadelphia, Abstract Ch-7, p 46Google Scholar
  18. Partington BP, Steeves RA, Su SL, Paliwal BR, Dubielzig RR, Wilson JW, Brezovich IA (1989) Temperature distributions, microangiographic and histopathologic correlations in normal tissue heated by ferromagnetic needles. Int J Hyperthermia 5: 319–327PubMedCrossRefGoogle Scholar
  19. Schreier K, Budihna M, Lesnicar H, HandlZeller L, Hand JW, Prior MV, Clegg ST, Brezovich IA (1990) Preliminary studies of interstitial hyperthermia using hot water. Int J Hyperthermia 6: 431–444PubMedCrossRefGoogle Scholar
  20. Stauffer PR, Sneed PK, Suen SA, Satoh T, Matsumoto K, Fike JR, Phillips TL (1989) Comparative thermal dosimetry of interstitial microwave and radiofrequency-LCF hyperthermia. Int J Hyperthermia 5: 307–318PubMedCrossRefGoogle Scholar
  21. Strohbehn JW, Mechling JA (1986) Interstitial techniques for clinical hyperthermia. In: Hand JW, James RJ (eds) Physical Techniques in Clinical Hyperthermia. Research Studies Press, Letchworth, pp 210–287Google Scholar
  22. Strohbehn JW, Bowers ED, Walsh JE, Douple EB (1979) An invasion microwave antenna for locally-induced hyperthermia for cancer therapy. J Microwave Power 14: 339–350Google Scholar
  23. Taylor LS (1980) Implantable radiators for cancer therapy by microwave hyperthermia. Proc IEEE 68: 142–148CrossRefGoogle Scholar
  24. Trembly BS (1985) The effects of driving frequency and antenna length on power deposition within a microwave antenna array used for hyperthermia. IEEE Transactions BME 32: 152–157CrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1992

Authors and Affiliations

  • M. Budihna
    • 1
  • H. Lesnicar
    • 1
  • L. Handl-Zeller
    • 2
  • K. Schreier
    • 2
  1. 1.Institute of OncologyLjubljanaYugoslavia
  2. 2.Clinic for Radiotherapy and RadiobiologyUniversity of ViennaViennaAustria

Personalised recommendations