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Clinical Practice of Interstitial Microwave Hyperthermia Combined with Iridium-192 Brachytherapy

  • M. H. Seegenschmiedt
  • R. Sauer
  • L. W. Brady
  • U. L. Karlsson

Abstract

Elevated temperatures in the range of 41°C–45°C in the whole body, in regional sections or localized areas of the human body in combination with radiotherapy have been used as a promising alternative to conventional treatment strategies, in particular for primary advanced tumors with a high probability for relapse and pretreated locally recurrent malignancies. Tumors of the head and neck, breast, brain as well as pelvic tumors may benefit from better local tumor control with impact on survival and quality of life (Kapp, 1986; Overgaard, 1989); improved local control may eventually result in a higher cure rate, better organ preservation and reduction of treatment morbidity. The clinical implementation of hyperthermia was stimulated by a better understanding of biological (Ben-Hur et al, 1974; Harisiadis et al, 1978; Miller et al, 1978; Gerner et al, 1983; Moorthy et al, 1984; Jones et al, 1989) and physiological effects (Dudar and Jain, 1984; Song, 1984; Reinhold and Endrich, 1986) on normal and tumor tissue as well as by newly developed heating techniques (Gautherie, 1989a; Hand, 1989), thermal modelling (Strohbehn et al, 1989) and improved invasive thermometry (Cetas, 1984). First promising clinical results (Kapp, 1989; Overgaard, 1989) have already been reported.

Keywords

Radiat Oncol Biol Phys Thermal Dose Thermal Quality Complete Tumor Response Advance Primary 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1992

Authors and Affiliations

  • M. H. Seegenschmiedt
    • 1
    • 2
  • R. Sauer
    • 1
  • L. W. Brady
    • 2
  • U. L. Karlsson
    • 2
  1. 1.Strahlentherapeutische Klinik, PoliklinikUniversität Erlangen-NürnbergErlangenFederal Republic of Germany
  2. 2.Department of Radiation Oncology and Nuclear MedicineHahnemann UniversityPhiladelphiaUSA

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