Experience with Radiofrequency-Local Current Field Interstitial Hyperthermia: Biological Rationale, Equipment Development, and Clinical Results

  • D. S. Kapp
  • S. D. Prionas


Considerable progress has been made in the clinical utilization of local hyperthermia (HT) as an adjunct to radiation therapy (XRT) in the treatment of superficially-located malignancies during the past 15 years (Anderson and Kapp, 1990). Evidence is accumulating demonstrating a correlation between the ability to heat tumors and the therapeutic outcome as measured by complete response rates or duration of local control (Kapp, 1988; Valdagni et al, 1988). While the parameters which best define our ability to heat tumors remain to be better elucidated, most studies show a relationship between some measure reflecting the average minimum or average intratumoral temperature distribution and outcome (Kapp, 1988). However, currently available non-invasive microwave or ultrasound heating techniques have limited field sizes and depths of penetration, making it difficult to obtain effective heating (goal ≥43°C for 30–60 minutes) at tumor depths of greater than 2–3 cm. Investigational systems employing radiative electromagnetic arrays or capacitive heating have some promise for deeper heating but, in general, result in regional rather than local heating of the tumors (Hiraoka et al, 1984; Petrovich et al, 1989).


Radiat Oncol Biol Phys Specific Absorption Rate Specific Absorption Rate Distribution Segmented Electrode Hyperthermia System 
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Copyright information

© Springer-Verlag/Wien 1992

Authors and Affiliations

  • D. S. Kapp
    • 1
  • S. D. Prionas
    • 1
  1. 1.Department of Radiation Oncology, School of MedicineStanford UniversityStanfordUSA

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